Page 217 - Phytochemistry 2 (06-PG 605)
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2- parthenolide exhibited in vitro cytotoxic activity against
some human cancer cell line
Its structure contains an α-methylene-γ-lactone ring and an
epoxide, both of which are able to interact with nucleophiles,
especially with cysteine thiol groups, causingG2/M-phase
arrest followed by apoptosis
Reduction of the methylene group at the lactone, provides
inactive derivative.
There are no published in vivo studies of parthenolide for
human cancer (preclinical studies)
