Page 63 - Pharmaceutics IV (02-06-01305)
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Parenterals: Excipients & additives
Nonaqueous vehicles
Water-miscible solvents
• The selected vehicle must be nonirritating, nontoxic in the amounts
administered, and not sensitizing. It must not exert a
pharmacologic activity of its own, nor may it adversely affect the
activity of the medicinal agent.
119
Parenterals: Excipients & additives
Nonaqueous vehicles
Oleaginous solvents
• They may be used in case of limited drug water solubility or its
susceptibility to hydrolysis
• Used in:
➢ Solutions: Oils are used to dissolve drugs with low aqueous
solubility and provide a mechanism to slowly release drug over
a long period of time.
➢ Emulsions: In TPN products, oils serve as a fat source and as
carriers for fat-soluble vitamins.
120
Salma E. EL-Habashy 60
