Page 66 - Pharmaceutics IV (02-06-01305)
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Parenterals: Excipients & additives
When?
• They should not be added to large volume parenterals (infusions), or
products intended for intraspinal, epidural, intracisternal or
intraocular injection. Unpreserved injections should be presented in
single-dose containers
125
Parenterals: Excipients & additives
Examples
• Benzyl alcohol, parabens, chlorbutanol, among others
• Parenteral products preserved with benzyl alcohol should not be
administered to neonates (fatal toxic reaction in low birth-weight
neonates).
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Salma E. EL-Habashy
