Page 70 - Pharmaceutics IV (02-06-01305)
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Parenterals: Excipients & additives
Buffers
Why?
• Buffers are included in parenteral products to maintain the pH of the
product at the desired optimum value.
• Changes in pH may arise due to interactions between an ingredient
in the formulation and the container, or from changes in storage
temperature.
133
Parenterals: Excipients & additives
Buffers
Buffer considerations:
• Parenteral products should be formulated to possess sufficient buffer
capacity to maintain proper product pH as well as be readily
overcome by the biological fluids. This way, they won’t disturb the
body's buffering systems when injected.
• LVP should not contain a pH buffer as the blood already has a buffer
effect property that could compete with the injected drug product.
134 67
Salma E. EL-Habashy
