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30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms
Microbiological stability
The contamination of the product with microorganisms can either render the product harmful to
the patient (infection hazard) or have an adverse effect on the product's properties (physical and
chemical properties of the product).
Microbiological deterioration is a critical factor in the stability of sterile products, once the
container is opened.
Injection products generally need to be used immediately when the container is opened and
ophthalmic products have a short in use life once opened.
How to avoid microbial growth:
Use of single dose products e.g. injections and eye drops.
In case of multidose products, preservatives are used to inhibit microbial growth during use.
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