Page 43 - Dosage 1-part2 -ebook_Neat
P. 43
30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms
Comparison between SVP and LVP
Aspect Small Volume Parenteral (SVP) Large Volume
Parenteral (LVP)
Volume Volumes of less than 1 ml and up to 100 ml. Volumes up to 1000
ml.
Container Include both single dose and multi-dose containers. They called
Type infusions.
Tonicity SVPs for IV injection may not be isotonic because the large Should be isotonic.
volume of blood rapidly dilute them. (SC, IM & ID should be
isotonic as hypertonic are tissue irritants)
The pH of SVPs can also vary from the physiological pH
pH because the blood buffering system rapidly readjust the pH Should have pH 7.4
after a small volume added.
Preservatives SVPs for single use may be free of anti-microbial Preservative-free
preservatives, but multi-dose vials usually have
preservatives to ensure sterility over multiple uses over a
certain period of time.
Special Cases SVP-intraocular and CNS- no preservative. For maintenance or
replacement
therapy.
2. Pharmaceutical classification
Refer to components of parenterals (solvents and additives)
2.1. Solutions
Most injectable products are solutions.
file:///C:/Users/sara talaat/Downloads/solutions and sterile sols.HTML 40/77
