Page 210 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

5- Terpineols OH OH OH

-H 2 O + +

OH OH

Terpin 5% H 2 SO 4 -Terpineol ---- ----

HCOOH
60%H 2 SO 4 H 3 PO 4

+
KHSO 3 O

Cineol

Terpinene Terpinolene
Dipentene -Pinene + Terpinolene

2) Bicyclic monoterpene alcohol e.g. Borneol & Isoborneol

• Odour: camphor-like odour

• N.B Isoborneol: is not a natural compound but probably a synthetic
product from reduction of camphor

• Uses: Antiseptic, diuretic and prevent calculi formation.

H
OH

OH H
Chemical reactions of Borneol & Isoborneol

Borneol Isoborneol

1) Borneol is readily oxidized to camphor using CuO but isoborneol is not

oxidized

H CuO/ O OH
Oxidation Reduction
OH

Camphor Borneol
Borneol Isoborneol

2) Isoborneol is more readily dehydrated to camphene, but borneol is not
dehydrated

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