Page 212 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

Use:

Fungistatic and potent anti termite.

Substrate for many reactions

2- Eudesmole:

α-eudesmol is Ca+2 channel blocker which help in treatment of migraine and acts as
neurogenic vasodilator

β-eudesmol is anticholine estrase, antiepileptic, neuromuscular blocker, Peptic ulcer
3- Cedrol:

Occurrence: cedar oil, Cupressus, Juniperus (juniper) oils

*Cedrol has toxic and possibly carcinogenic properties.

**Recent research suggests that cedrol strongly attracts pregnant female mosquitoes after
they have fed, which can be used to create cedrol-baited traps

C. Aromatic alcohols

e.g. Benzyl alcohol

⚫ Occurrence: in balsams e.g. Storax

⚫ N.B. Benzyl alcohol is not a terpene alcohol.

⚫ Isolation: (through additive derivative with CaCl2 in dry ether): Oil + Anhydrous
CaCl2 → addition complex →(Δ/H2O)→Benzyl alcohol is regenerated.

It is colorless liquid with faint aromatic odor become like bitter almond odor on exposure to
air due to oxidation to benzaldehyde. Benzyl alcohol yield benzoic acid on oxidation with
H2SO4 , chromic acid or with pot. permenganate.
Use: Benzyl alcohol is used local anaethetic as fixative and diluent in perfumery

II- Phenols and Phenolic Ethers

• Importance: Phenols are very important antiseptic and germicidal agents e.g. thymol,
eugenol, …etc

• Most phenols & phenol ethers have powerful aromatic odour and flavour e.g. oil of
clove & oil of anise

• Isolation:

1. Fractional distillation

2. GCMS and HPLC

193