Page 206 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

-by formation of phthalate ester followed by decomposition with alc. KOH
and extraction with ether.

Uses: 1- In pefrumes, cosmetics and soap industries to impart a rose like odour.

2- insect repellent, good mosquito repellent at short distances.

3- mite attractant

2) Geraniol and Nerol ( Geranium رطعلا تابن )

Ocurrence: in geranium oil & neroli oil (the blossom of the bitter orange tree,
lavander oil, coriander oil usually occurs in combination)

Isolation: Geraniol forms a crystalline complex with anhydrous CaCl 2 which is
insoluble in benzene or ether and decomposed in water into geraniol and CaCl 2,
while nerol does not form such complex with CaCl 2

CH 2 OH

CH 2 OH

Geraniol Nerol
(trans) (Cis)

Uses: Geraniol and nerol have agreable rose-like odour, so they are widely used
in perfumes and cosmetic industries.
o Geraniol is the most widely used isolate in many perfume or
cosmetic industry.
o Geraniol is used as mosquito repellent.

o Both are air sensitive and become disagreable after sometime.
o Geraniol is considered a severe eye (and moderate skin) irritant.

3) Linalol = (Linalool)

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