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                Acta Ophthalmologica 2010


                 Glaucoma Trial Group (2003): Factors for  field damage in patients with normal-tension  bonic anhydrase inhibitor for primary
                 glaucoma progression and the effect of  glaucoma. Jpn J Ophthalmol 50: 38–43.  open-angle glaucoma and ocular hyperten-
                 treatment (the Early Manifest Glaucoma  Nouri-Mahdavi K, Hoffman D, Coleman  sion Brinzolamide Primary Therapy Study
                 Trial). Arch Ophthalmol 121: 48–56.  AL, Liu G, Li G, Gaasterland D, Caprioli  Group. Am J Ophthalmol 126: 400–408.
                Leske MC, Heijl A, Hyman L, Bengtsson B,  J; Advanced Glaucoma Intervention Study  Spry PGD, Sparrow JM, Diamond JP &
                 Dong L, Yang Z; EMGT Group (2007):  (2004a): Predictive factors for glaucoma-  Harris HS (2005): Risk factors for progres-
                 Predictors of longterm progression in the  tous  visual  field  progression  in  the  sive visual field loss in primary open-angle
                 Early Manifest Glaucoma Trial. Ophthal-  Advanced Glaucoma Intervention Study.  glaucoma. Eye 19: 643–651.
                 mology 114: 1965–1972.         Ophthalmology 111: 1627–1635.  Stams T, Chen Y, Boriack-Sjodin PA et al.
                Lieb WE, Cohen SM, Merton DA, Shields  Nouri-Mahdavi K, Hoffman D, Gaasterland  (1998). Structures of murine carbonic anhy-
                 JA, Mitchell DG & Goldberg BB (1991):  D & Caprioli J (2004b): Prediction of  drase IV and human carbonic anhydrase II
                 Colour Doppler imaging of the eye and  visual field progression in glaucoma. Invest  complexes with brinzolamide: molecular
                 orbit: technique and normal vascular anat-  Ophthalmol Vis Sci 45: 4346–4351.  basis of isoenzyme-drug discrimination.
                 omy. Arch Ophthalmol 109: 527–531.  Nouri-Mahdavi K, Hoffman D, Ralli M &  Protein Sci 7: 556–563.
                March WF & Ochsner KI (2000): The long-  Caprioli J (2007): Comparison of methods  Stewart WC, Kolker AE, Sharpe ED, Day
                 term safety and efficacy of brinzolamide  to predict visual field progression in glau-  DG, Holmes KT, Leech JN, Johnson M &
                 1.0% (Azopt) in patients with primary open-  coma. Arch Ophthalmol 129: 1176–1181.  Cantrell JB (2000): Factors associated with
                 angle glaucoma or ocular hypertension. The  Ornek K, Gullu R, Ogurel T & Ergin A  longterm progression or stability in pri-
                 Brinzolamide Longterm Therapy Study  (2008): Short-term effect of topical brinzo-  mary open-angle glaucoma. Am J Ophthal-
                 Group. Am J Ophthalmol 129: 136–143.  lamide on human central corneal thickness.  mol 130: 274–279.
                Martinez A & Sanchez M (2005): Predictive  Eur J Ophthalmol 18: 338–340.  Strahlman E, Tipping R, Vogel R & the
                 value of colour Doppler imaging in a pro-  Ozturk F, Ermis SS & Inan UU (2007): Com-  International Dorzolamide Study Group
                 spective study of visual field progression in  parison of the ocular hypotensive effects of  (1995).  A  double-masked,  randomized
                 primary open-angle glaucoma. Acta Oph-  bimatoprost and timolol–dorzolamide com-  1-year study comparing dorzolamide (Trus-
                 thalmol Scand 83: 716–723.     bination in patients with elevated intraocu-  opt), timolol, and betaxolol. Arch Ophthal-
                Martinez A & Sanchez M (2006): A compari-  lar  pressure:  a  6-month  study.  Acta  mol 113: 1009–1016.
                 son of the effects of 0.005% latanoprost  Ophthalmol Scand 85: 80–83.  Sugrue MF (2000): Pharmacological and
                 and fixed combination dorzolamide ⁄ timolol  Pillunat LE, Bo ¨ hm AG, Ko ¨ ller AU, Schmidt  ocular hypotensive properties of topical
                 on retrobulbar haemodynamics in previ-  KG, Klemm M & Richard G (1999): Effect  carbonic anhydrase inhibitors. Prog Retin
                 ously untreated glaucoma patients. Curr  of topical dorzolamide on optic nerve head  Eye Res 19: 87–112.
                 Med Res Opin 22: 67–73.        blood flow. Graefes Arch Clin Exp Oph-  Vesti E, Johnson CA & Chauhan BC (2003):
                Martinez A & Sanchez M (2007): Retrobulbar  thalmol 237: 495–500.  Comparison of different methods for detect-
                 haemodynamic effects of the latanoprost ⁄  Pourcelot L (1975): Indications de l’ultrasonog-  ing glaucomatous visual field progression.
                 timolol and the dorzolamide ⁄ timolol fixed  raphie Doppler dans l’etude des vaisseaux  Invest Ophthalmol Vis Sci 44: 3873–3879.
                 combinations in newly diagnosed glaucoma  peripheriques. Rev Prat 25: 4671–4680.  Weinstock FJ (1973): Ophthalmic hazards of
                 patients. Int J Clin Pract 61(5): 815–821.  Riva CE & Petrig BL (1995): Choroidal  hypotensive drugs. JAMA 224: 1039.
                Martinez A & Sanchez M (2008a): Effects of  blood flow by laser Doppler flowmetry.  Wirtitsch MG, Findl O, Kiss B, Petternel V,
                 dorzolamide 2% added to timolol maleate  Opt Eng 34: 746–752.  Heinzl H & Drexler W (2003): Short-term
                 0.5% on intraocular pressure, retrobulbar  Satilmis M, Orgul S, Doubler B & Flammer  effect of dorzolamide hydrochloride on cen-
                 blood flow, and progression of visual field  J (2003): Rate of progression of glaucoma  tral corneal thickness in humans with cornea
                 damage in patients with primary open-  correlates with retrobulbar circulation and  guttata. Arch Ophthalmol 121: 621–625.
                 angle glaucoma: a single-centre, 4-year,  intraocular pressure. Am J Ophthalmol  Wirtitsch MG, Findl O, Heinzl H & Drexler
                 open-label study. Clin Ther 30: 1120–1134.  135: 664–669.    W (2007): Effect of dorzolamide hydro-
                MartinezA &Sanchez M(2008b): Ocular haemo-  Sato S, Hirooka K, Baba T, Yano I & Shiraga  chloride on central corneal thickness in
                 dynamics in pseudoexfoliative and primary  F (2008): Correlation between retinal nerve  humans with cornea guttata. Arch Oph-
                 open-angle glaucoma. Eye 22(4): 515–520.  fibre layer thickness and retinal sensitivity.  thalmol 125(10): 1345–1350.
                Martinez A & Sanchez M (2008c): Retrobulbar  Acta Ophthalmol 86: 609–613.  Wistrand PJ (2000): Carbonic anhydrase inhi-
                 haemodynamic parameters in pseudoexfoli-  Schmetterer L, Lexer F, Graselli U, Findl O,  bition in ophthalmology: carbonic anhyd-
                 ation syndrome and pseudoexfoliative glau-  Eichler HG & Wolzt M (1996): The effect of  rases in cornea, lens, retina and lacrimal
                 coma. Graefes Arch Clin Exp Ophthalmol  different mixtures of O 2 and CO 2 on ocular  gland. EXS 90: 413–424.
                 246: 1341–1349.                fundus pulsations. Exp Eye Res 63: 351–355.  Zeitz O, Galambos P, Weirmann A et al.
                Martinez A, Gonzalez F, Capeans C, Perez R  Sender S, Gros G, Waheed A, Hageman GS  (2006): Glaucoma progression is associated
                 & Sanchez-Salorio M (1999): Dorzolamide  & Sly WS (1994): Immunohistochemical  with decreased blood flow velocities in the
                 effect on the ocular blood flow. Invest  localization of carbonic anhydrase IV in  short posterior ciliary artery. Br J Ophthal-
                 Ophthalmol Vis Sci 40: 1270–1275.  capillaries of rat and human skeletal mus-  mol 90: 1245–1248.
                Mu ¨ skens RPHM, De Voogd S, Wolfs RC,  cle. J Histochem Cytochem 42: 1229–1236.
                 Witteman JC, Hofman A, de Jong PT,  Shall K & the Brinzolamide Primary Therapy
                 Stricker BH & Jansonius NM (2007):  Study Group (2000): The efficacy and safety
                 Systemic antihypertensive medication and  of brinzolamide 1% ophthalmic suspension  Received on October 20th, 2008.
                 incident open-angle glaucoma. Ophthal-  (Azopt) as a primary therapy in patients  Accepted on February 14th, 2009.
                 mology 114: 2221–2226.         with open-angle glaucoma or ocular hyper-
                Nagelhus EA, Mathiisen TM, Bateman AC,  tension. Surv Ophthalmol 44: 155–162.  Correspondence:
                 Haug FM, Ottersen OP, Grubb JH,  Siesky B, Harris A, Cantor LB et al. (2008):  Antonio Martı´nez
                 Waheed A & Sly WS (2005): Carbonic  A comparative study of the effects of  c ⁄ o Rosalia de Castro, 80 5º C
                 anhydrase XIV is rich in specific membrane  brinzolamide and dorzolamide on retinal  15895 Ames
                 domains of retinal pigment epithelium,  oxygen saturation and ocular microcircula-  La Corun ˜ a
                 Mu ¨ ller cells, and astrocytes. Proc Natl  tion in patients with primary open-angle  Spain
                 Acad Sci U S A 102: 8030–8035.  glaucoma. Br J Ophthalmol 92: 500–504.  Tel: +34 6461 78104
                Nakagami T, Yamazaki Y & Hayamizu F (2006):  Silver LH (1998): Clinical efficacy and safety  Fax: +34 9819 51670
                 Prognostic factors for progression of visual  of brinzolamide (Azopt), a new topical car-  Email: tontxu_1999@yahoo.com

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