Page 9 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

viii Contents

Other Toxins
VetBooks.ir Concluding Remarks and Future Directions 54 Mechanism of Action 75
75
Toxicity
54
References
Treatment
76
54
Concluding Remarks 77
4. Epidemiology of Animal Poisonings Lewisite 77
in Asia Background 77
Pharmacokinetics/Toxicokinetics 77
Pawan K. Gupta Mechanism of Action 77
Introduction 57 Toxicity 77
Pesticides (Agrochemicals and Fertilizers) 57 Treatment 78
Metals 58 Concluding Remarks 79
Lead (Pb) 58 Phosgene Oxime 79
Mercury (Hg) 59 Background 79
Arsenic (As) 59 Pharmacokinetics/Toxicokinetics 79
Copper (Cu) 59 Mechanism of Action 79
Nonmetals and Metalloids 59 Toxicity 79
Selenium (Se) 59 Treatment 80
Nitrate and Nitrite 60 Concluding Remarks 80
Fluorosis 60 Cyanide and Hydrogen Cyanide 80
Drugs and Related Compounds 61 Background 80
Mycotoxins 62 Pharmacokinetics/Toxicokinetics 80
Household Products 63 Mechanism of Action 81
Methyl Isocyanate (Union Carbide Plant Toxicity 81
Disaster in Bhopal) 64 Treatment 81
Feed Associated Toxicants 64 Concluding Remarks 82
Plastic Bags 65 Military Nerve Agents 82
Other Toxins 66 Background 82
Radiations Effects of the Hiroshima and Pharmacokinetics/Toxicokinetics 83
Nagasaki Atomic Bombs 66 Mechanism of Action 83
Concluding Remarks and Future Directions 66 Toxicity 83
References 66 Treatment 84
Further Reading 69 Concluding Remarks 85
References 85
5. Chemicals of Terrorism

Tina Wismer 6. Regulatory Considerations in
Introduction 71 Veterinary Toxicology: An FDA
Chlorine Gas 71 Perspective
Background 71
Pharmacokinetics/Toxicokinetics 72 Susan J. Bright-Ponte, Tong Zhou and
Mechanism of Action 72 Michael J. Murphy
Toxicity 72 Introduction 89
Treatment 72 Brief History of the Food and Drug
Concluding Remarks 73 Administration 89
Phosgene 73 FDA Organization 90
Background 73 FDA Center for Veterinary Medicine 91
Pharmacokinetics/Toxicokinetics 73 Overview 91
Mechanism of Action 73 Regulation of Animal Health Products:
Toxicity 73 Jurisdiction Considerations and Regulatory
Treatment 74 Definitions 91
Concluding Remarks 74 New Animal Drug Approval 92
Mustard Gas 74 Target Animal Safety Evaluation 92
Background 74 Human Food Safety Assessment 93
Pharmacokinetics/Toxicokinetics 74 Approval 96