Page 11 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

x Contents

VetBooks.ir 10. Toxicoproteomics in Diagnostic Conclusion 190
192
Acknowledgment
Toxicology
References
192
Christina R. Wilson and Stephen B. Hooser
Introduction 163 Further Reading 192
Analytical Tools for Proteomic Analyses 163
The Proteome and Sample Complexity 163 Section II
Two-Dimensional Gel Electrophoresis 163 Organ Toxicity
High Performance Liquid Chromatography 164
Protein and Peptide Microarrays 165 12. Nervous System Toxicity
Mass Spectrometry 165
Bioinformatics Tools 166 Donna Mensching and Camille DeClementi
Proteomics Applications in Diagnostic
Introduction 197
Toxicology 167
Structural Toxicoses 197
Aquatic Toxicology and Pesticides 168 Neuronopathy 197
Hepatotoxicity 168 Axonopathy 199
Toxins 168 Myelinopathy 199
Concluding Remarks and Future Directions 169 Functional Toxicoses 200
References 169 Acetylcholine 200
Catecholamine Neurotransmitters 202
11. Toxicology and the Law Serotonin 203
Glycine 203
Michael J. Murphy
GABA 204
Introduction 173 Glutamate/Aspartate 205
Reasons for Conducting Toxicology Analyses 173 Histamine 205
When the Reason for Testing the Sample is Mixed Neurotransmitter Effects 205
Known 174 Ion Channels 206
When the Reason for Testing the Sample Sodium Channels 206
is Not Known or Changes After Testing 175 Potassium Channels 207
Hypothetical Case 175 Chloride Channels 208
Jurisdiction: What are the Rules and Other Mechanisms of Neurotoxicity 208
Who Decides the Winner ? 177 Concluding Remarks and Future Directions 208
Standard of Proof: How Sure Do References 211
I Need to Be? 178
Evidence 179
Documents 179 13. Respiratory Toxicity
Specimens 180
Deon van der Merwe
Testimony 180
Admissibility of Expert Testimony 181 Introduction 215
Frye 181 The Upper Airways 215
Daubert 182 Normal Function 215
Is the Expert Qualified? 185 Toxic Diseases of the Nasal Passages 216
Has the Person Been Trained and Educated Toxic Diseases of the Conducting Airways 216
in the Discipline of Toxicology? 185 The Gas Exchange Region 216
Has the Person Been Certified as a Normal Function 216
Toxicologist? 185 General Principles in the Pathogenesis
Do Other Criteria Support an Argument of Lung Damage Caused by Chemicals 218
That the Person is a Toxicologist? 186 Oxidant Burden 218
General Causation 186 Toxic Inhalant Gases 218
Specific Causation: The Differential Diagnosis 187 Particle Size and Clearance 220
Application of Daubert in Toxicology Cases 188 Lung Injury 221
Some Questions to Consider Acute Responses to Lung Injury 221
When Using Laboratory Results 189 Chronic Responses of the Lung to Injury 222