Page 12 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Contents xi

VetBooks.ir References 223 Steatohepatitis 247
Agents Known to Produce Lung Injury
248
in Animals
Hepatic Fibrosis
248
Cirrhosis
224
Pigment Accumulation 248
Hepatic Neoplasia 249
14. Cardiovascular Toxicity Megalocytosis 249
Mechanisms of Liver Damage 249
Csaba K. Zoltani
Oxidative Stress Mediated by Free Radicals 250
Introduction 227 Disruption of Calcium Homeostasis and
Plant-Induced Cardiotoxicity 227 Cell Membrane Damage 251
Phytochemicals Affecting the Cardiac Mitochondrial Injury 251
System 228 Disruption of Cytoskeleton 252
Glycoside-Containing Plants 228 Cholestasis 252
Cyanide-Containing Plants 230 Hepatogenous Photosensitization 252
Alkaloid-Containing Plants 230 Inhibition of Tissue Repair Response 253
Oxalate-Containing Plants 232 Idiosyncratic Reactions 253
Nitrate-Containing Plants 233 Concluding Remarks and Future Directions 254
Metal-Induced Cardiac Toxicity 233 References 255
Arsenic 233
Ionophores (Antibiotics) 233 16. Renal Toxicity
Fertilizers 233
Herbicides 234 Sharon M. Gwaltney-Brant
Insecticides and Other Pesticides 234
Introduction 259
Organophosphates and Carbamates 234
Functional Anatomy 259
Amitraz 234
Toxic Effects on the Kidney 261
Metaldehyde 234
Acute Renal Failure 261
Mycotoxins 235
Chronic Renal Failure 261
Ancillary Causes of Cardiac Toxicity 235
Patterns of Toxic Renal Injury 262
Anthropods 235
Glomerular Injury 265
Hymenoptera 235
Proximal Tubular Injury 265
Ophidian 235
Distal Nephron/Renal Papillary Injury 266
Cantharidin 236
Nephrotoxic Agents 266
Concluding Remarks and Future Directions 236
Mycotoxins 266
References 236
Drugs 266
Metals 267
Plants 268
15. Liver Toxicity
Miscellaneous 269
Karyn Bischoff, Motoko Mukai and Concluding Remarks and Future Directions 271
Shashi K. Ramaiah References 271
Introduction 239
Structural and Functional Organization 17. Reproductive Toxicity and Endocrine
of the Liver 239 Disruption
Lobule and Acinus 239
Tim J. Evans
Diverse Function of the Liver 241
Cell Types of the Liver 242 Introduction 273
Factors Influencing Toxic Liver Injury 243 Important Definitions and Concepts 273
Uptake and Concentration of Xenobiotics 243 Reproduction 273
Bioactivation and Metabolism 244 Reproductive Toxicity 274
Inflammation 246 Hormones and Hormone Receptors 275
Types of Toxicant-Induced Liver Injury 246 Endocrine Disruption 276
Cell Death 246 Normal Animal Reproduction 280
Hepatic Steatosis 247 Neuroendocrine Control of Reproduction 280