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Light’s path to all these places in the body                51




                   P




                   Pp

                                                                        Ep


                   Pa



                                                                                                                t
                            ton                   toff


                                      1                   ton
                             fp =                DC =                Pa = Pp  x  DC        Ep = Pp  x  ton
                                   ton  +  toff         ton  +  toff

                                                                                 x
                                                          x
                                                     = ton    fp        = Pp  x  ton    fp
                                                     Complete combinations

                                             OR  toff)   AND    OR DC)              OR Pa)
                                        (ton                (fp           AND (Pp
                                                                PLUS
                                                             2
                                              Spot size (cm )  AND  Wavelength (nm)
                   Figure 6.8 Relevant parameters describing pulsed light.


                   DC to get what you need). Then you need one of the   as a laser pointer (in the low milliwatt range), which
                   power values to determine the energy per pulse.   would take hours or days to deliver the necessary clin-
                     Obviously the wavelength and spot size round out   ical dose.
                   the story, wavelength giving you information as to the   But how long is too long?
                   absorption/scatter/penetration/target chromophore of
                   the light, and spot size giving you the values of energy   6.7 Treatment time and reciprocity
                   density (dose) and power density.
                     All that said, the average power P  is what matters   In general, a serious question is whether the accumula-
                                                  a
                   when it comes to understanding how much time is   tion of dose is a sufficient predictor of clinical effect.
                   required to deliver your clinical effect. You will hear the   With respect to pulsing, it is clear that the rule of reci-
                   term “superpulsed” thrown around a lot in this indus-  procity (i.e. that total exposure or dose determines clin-
                   try. That word in itself can be good or bad. In the good   ical effect) does not hold across the board. The whole
                   form,  there  are  superpulsed  lasers  that  deliver  high   beneficial nature of pulsing relies on a specific timing of
                   average power, but with enough time between pulses   pulses (either in the time they are on or in the time the
                   to allow for thermal relaxation of the tissue. In the bad   light is off between them) and so it is clear to see that if
                   form, there are superpulsed lasers that have substan-  you modified the pulse structure (e.g. by decreasing the
                   tially high peak power, but their pulses are so short   peak power but increasing the pulse width proportion-
                   and so few that the total energy delivered per second   ally) you could expect a very different intra-tissue effect,
                   (average power, by definition) is only about as much   even though the total energy per pulse and therefore










         REDONDO PRINT (4-COL BLEED).indd   51                                                                         08/08/2019   09:47
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