Page 514 - Traité de chimie thérapeutique 6 Médicaments antitumoraux

472 MEDICAMENTS INDUISANTOUSTABILISANTDES COUPURES DE L'ADN

Cette modification, réalisée dans AQ4N rend l'azote terminal électriquement neutre et
entraîne une faible toxicité pour I'ADN, dans les conditions physiologiques. Par contre,
dans les tissus hypoxiques, ce composé est activé selon un processus de bioréduction
dont le mécanisme est décrit dans le chapitre 39.

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