Page 237 - Medicinal Chemistry Self Assessment
P. 237
226 Medicinal Chemistry Self Assessment
6. Assess each of the possible metabolic products generated from sitagliptin and determine which
phase I metabolic transformation has occurred.
A
B
C
D
Answer
Name of Metabolic Transformation
A Benzylic oxidation
B Oxidative deamination
C Amide hydrolysis
D Aromatic hydroxylation
