Page 134 - phytochemistry I - PharmD Clinical

Dicoumarols are dimers of 4-hydroxycoumarins. They are powerful oral
anticoagulants such as: acenocoumarol, phenprocoumon, warfarin.

Mechanism of anticoagulant activity:

Dicoumarols arecompetitive inhibitor of vitamin K epoxide reductase, an
enzyme that recycles vitamin K, thus causing depletion of active vitamin
K in blood. This prevents the formation of the active form of prothrombin
and several other coagulant enzymes.

warfarin

3. Skimmin

O-Glycosylated derivative, 7-O-β-D-glucopyranosyl umbelliferone.
Occurs naturally.

Uses:

• Precursor in the biosynthesis of umbelliferone.
• Potential anti-inflammatory compound.
• Potent anti-amoebic compound.

4. Poisonous coumarins

Aflatoxins
Aflatoxins are coumarin derivatives.

• Aflatoxins are poisonous hepatotoxic
carcinogens that are produced by

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