Page 133 - phytochemistry I - PharmD Clinical

Coumarin (2H-chromen-2-one) (benzo α-pyrone) is an aromatic organic
chemical compound in the benzopyrone chemical class, although it may
also be seen as a subclass of lactones. It is widely distributed within the
Rutaceae and Apiaceae (Umbelliferae) families.

1. Umbelliferone

Umbelliferon occurs in free form in the oleo-gum resin Galbanum & in
combined form in Asafetida.

Umbelliferone (7-hydroxycoumarin)

Chemical test:

Free umbelliferon is distinguished from combined umbelliferon, by
addition of ammonia to its alcoholic extract giving blue fluorescence.
While, combined umbelliferone in asafetida responds positively only after
acid hydrolysis.

Uses:

• It exhibits anti-inflammatory activities
• Protection of DNA against gamma irradiation damage.
• An anti-hyperglycemic effect.
• The ultraviolet activity of umbelliferone led to its use as a sunscreen

agent, and an optical brightener for textiles.
• Umbelliferone can be used as a fluorescence indicator for metal ions

such as copper and calcium.
• It acts as a pH indicator in the range 6.5-8.9.

2. Dicoumarols

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