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1234  Hyperchloremia                                                                                 Hyperemia



            Hyperchloremia                                       Hypercholesterolemia: Mnemonic
  VetBooks.ir  Pseudohyperchloremia                              Having pepperoni pizza @ night can cause instant death.


              Lipemic samples (colorimetric methods)
              Potassium bromide therapy                          H—hypothyroidism
                                                                 P—postprandial
            Excessive Loss of Sodium Relative to Chloride        P—pancreatitis
              Diarrhea (very common cause)                       N—nephrotic syndrome
                                                                 C—Cushing’s
            Excessive Gain of Chloride Relative to Sodium        C—cholestasis
              Therapy with chloride salts (NH 4 Cl, KCl)         I—idiopathic breed related
              Total parenteral nutrition                         D—diabetes mellitus
              Fluid therapy (e.g., 0.9% NaCl, hypertonic saline, KCl-supplemented fluids)
              Salt poisoning
            Renal Chloride Retention
              Renal failure
              Renal tubular acidosis
              Hypoadrenocorticism*
              Diabetes mellitus*
              Chronic respiratory alkalosis
              Drug-induced: acetazolamide, spironolactone
            Other Causes
              Exercise
           *May be associated with corrected hypochloremia in cats.
            −
                                     +
                              +
                    −
           Cl  (corrected) = Cl  (measured) × (Na  [normal]/Na  [measured]).
           Modified from de Morais HSA: Chloride ion in small animal practice: the forgotten ion. J Vet Emerg
           Crit Care 2:11-24, 1992.


            Hyperemia



            Differential Diagnosis Item   Key Feature(s)
            Generalized Hyperemia
              Hyperthermia-induced        Potentially incidental finding unless supported by the presence of other infectious, inflammatory, immune-mediated,
                                          neurogenic, environmental, or toxic etiologies
              Carbon monoxide intoxication  History; otherwise, confirmation requires co-oximetry (very limited availability). Can occur with extreme hemolysis, resulting
                                          in hyperemia despite anemia.
              Anaphylaxis/drug reaction   History of exposure and presence of supporting clinical signs
              Mast cell tumor, pheochromocytoma  Episodic hyperemic episodes
              Contact dermatitis          History of exposure to potential allergen
              Cardiac, hepatic, venous occlusion  Decreased venous return states also associated with additional clinical signs
              Hyperdynamic phase of shock  Evidence of severe illness such as sepsis or heatstroke
              Drugs and toxins            Alpha-adrenergic receptor blocker, alcohol ingestion, cyanide, acepromazine
              Erythrocytosis              Primary or secondary causes of erythrocytosis; confirmed with CBC or packed cell volume
              Hemoglobinemia              Hemolysis or administration of synthetic hemoglobin
            Regional Hyperemia
              External constriction       Examine for presence of a rubber band, collar, identification band, tight bandaging.
              Allergen exposure           Insect bites may result in localized swelling, usually the face in dogs and paws in cats. Check for history and presence of
                                          exposure, such as urticaria, vomiting, poor peripheral perfusion.
              Internal obstruction        Comparative pulse oximetry and blood pressure readings are suggestive, supported by ultrasound evaluation.
           Reproduced from the third edition in edited form.

           THIRD EDITION AUTHOR: Lisa M. Abbott, DVM, MRCVS






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