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1036   PART VIII   Reproductive System Disorders




  VetBooks.ir  Drugs Used in Reproductive Disorders—cont’d          CANINE DOSE             FELINE DOSE

             USE
                                                 TRADE NAME
                                DRUG
             Follicular ovarian   GnRH           Cystorelin, Abbott;   50-100 µg/bitch IM q24h,
               cysts            hCG                Various           3 days
                                                                    500 IU/kg IM once
             Increase sperm     PGF 2α           Lutalyse, Pfizer   0.1 mg/kg SC, 15 min
               ejaculated                                            before collection
             Luteal ovarian cysts  Cloprostenol                     1-3 µg/kg SC q24h to
                                                                     effect
             Mammary            Aglepristone ‡   Alizine, Virbac    NA                      20 mg/kg SC once
               hyperplasia                                                                  or
                                                                                            10 mg/kg SC, 2
                                                                                              consecutive days
             Ovulation induction   GnRH          Cystorelin, Abbott                         25 µg/cat IM, once or
               during estrus                                                                  twice, q24h
                                hCG              Various                                    75-100 IU/cat IM, once
                                                                                              or twice, q24h
             Preterm labor      Terbutaline      Brethine, Ciba     0.03 mg/kg PO q8h       0.03 mg/kg PO q8h
                                                   Geigy
             Priapism           Gabapentin                          10-20 mg/kg PO q 8-12h   5-10 mg/kg PO q
                                                                     to effect                8-12h to effect
                                Terbutaline                         0.03 mg/kg PO q8-12h to   0.03 mg/kg PO q8-12h
                                                                     effect                   to effect
                                Ephedrine                           2-3 mg/kg PO q8-12h to   2-3 mg/kg PO q8-12h
                                                                     effect                   to effect
             Puerperal          Calcium gluconate   Various         10% solution, slow IV to   10% solution, slow IV to
               hypocalcemia      10% IV,                             effect (1-20 mL)         effect (1-2 mL)
                                 followed by Ca
                                 gluconate SC
                                 and then
                                 calcium
                                 gluconate,
                                 lactate, or
                                 carbonate PO
                                                 Example: Tums      10-30 mg/kg PO q8-12h   500-600 mg PO q24h
                                                                     to effect
             Pyometra (open) and  Cloprostenol                      1-3 µg/kg SC q24h to    1-3 µg/kg SC q24h to
               postpartum metritis                                   effect and appropriate   effect and appropriate
                                                                     antibiotics              antibiotics

            GnRH, Gonadotropin-releasing hormone; IM, intramuscular; IV, intravenous; LH, luteinizing hormone; NA, not applicable; PO, by mouth; SC,
            subcutaneous.
            *No obstruction.
            † May initially produce proestrus.
            ‡ Will cause abortion if pregnant.
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