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1134   PART IX   Nervous System and Neuromuscular Disorders


                                                                              Physical exam,        Non-neurologic
                                                                              neurologic exam,      life-threatening
                                                                                                       injuries
                                                                            ± laboratory evaluation
  VetBooks.ir                                    Dorsal                     Localize spinal injury  Address, stabilize


                                                                 Administer glucocorticosteroids
                                                                  Methylprednisolone sodium succinate 30 mg/kg IV as slow bolus
                                                                    once then 15 mg/kg at 2h, 6h
                                                 Middle
                                                                         Restrain on board if necessary
                                                 Ventral

                                                                  Unstable spine             Stable spine
                                                                 2-3 compartments           1 compartment
                                                                    involved                   involved

                                                                                               CT ± to
                                                                  SURGERY     Compression
                                                                                          assess compression
                                                     Dorsal
                                                                                            No compression

                                                     Middle                             CONSERVATIVE THERAPY

                                                     Ventral        FIG 65.4
                                                                    Algorithm for management of acute spinal trauma.

            FIG 65.3
            Illustration of the three-compartment model for radiographic
            evaluation of spinal fractures. Dorsal compartment includes    TABLE 65.3
            articular facets, laminae, pedicles, spinous processes, and
            supporting ligaments. Middle compartment contains the   Narcotic Analgesics Used to Treat Spinal Pain in Dogs
            dorsal longitudinal ligament, dorsal annulus, and the floor
            of the spinal canal. Ventral compartment consists of the   DRUG              DOSAGE
            remainder of the vertebral body and the annulus, nucleus
            pulposus, and ventral longitudinal ligament. When two or   Oxymorphone       0.05 mg/kg IM
            three of the compartments are damaged or displaced,
            surgical stabilization is indicated.                  Morphine               0.3-2.2 mg/kg, SC or IM
                                                                  Butorphanol            0.4-0.8 mg/kg SC
                                                                  Buprenorphine          0.02-0.06 mg/kg, IM or SC

            injuries and maintenance of patient blood pressure, perfu-  IM, Intramuscular; SC, subcutaneous.
            sion, and oxygenation. There is weak experimental evidence
            that intravenous (IV) administration of methylprednisolone
            sodium  succinate (MPSS),  a  highly  soluble corticosteroid   will help prevent pressure sores. All impaired limbs should
            with neuroprotective effects exerted primarily by its actions   be moved repeatedly through a full range of motion many
            as a free-radical scavenger, within 8 hours of trauma may   times each day. Maintenance of an indwelling urinary cath-
            be beneficial (Fig. 65.4). Unfortunately, a few dogs treated   eter ensures a dry animal but may increase the risk of urinary
            according to this protocol suffer from serious gastro-  tract infection, particularly when kept in place for longer
            intestinal complications. Adverse effects should be moni-  than 3 days. When long-term care is necessary, the bladder
            tored and may be decreased by concurrent administration of   should be gently expressed or catheterized and emptied four
            an H 2 -receptor blocker (oral [PO] or IV ranitidine, 2 mg/kg   to six times daily and urinary tract infections treated as they
            q8h; or famotidine, 0.5 mg/kg PO or IV q24h), a proton pump   occur. In animals with UMN bladders (see Chapter 58) or
            inhibitor (omeprazole, 0.7-1.5 mg/kg/day) or a synthetic   those with urethral spasm, medical therapy (phenoxybenza-
            prostaglandin E 1  analog (misoprostol, 2-5 µg/kg PO q8h),   mine, 0.25-0.5 mg/kg PO q8h, and diazepam, 0.5 mg/kg
            and a mucosal protectant (sucralfate, 0.25-1 g PO q8h; see     q8h) may help relax the urethral sphincter, making bladder
            Chapter 28).                                         expression easier and less traumatic. When an animal starts
              Intensive nursing care is critically important in dogs and   to regain voluntary motion in the limbs, physical therapy is
            cats managed conservatively or surgically. Narcotic analge-  increased; hydrotherapy or swimming stimulates voluntary
            sics may be administered as needed (Table 65.3). Thickly   movement, improves circulation to the limbs, and cleans
            padded, clean, dry cages and frequent turning of the patient   the skin.
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