Page 264 - Small Animal Internal Medicine, 6th Edition

236 PART I Cardiovascular System Disorders

VetBooks.ir Drugs Used in Cardiovascular Disorders—cont’d

TRADE
GENERIC NAME NAME DOG CAT

Other Vasodilators
Hydralazine Apresoline 0.5-1 mg/kg initial (up to 2-3 mg/kg) PO 2.5 (up to 10) mg/cat PO q12h
q12h
For acute decompensated CHF: 0.5-1 mg/
kg PO, repeat in 2-3 hours if needed,
then q12h, or low dose IV (see Chapter
3 and Box 3.1)
For hypertensive crisis: (0.1-) 0.2 mg/kg,
IV or IM, q2h as needed
Amlodipine besylate Norvasc 0.1-0.3 (-0.5) mg/kg PO q(12-)24h; as 0.625 (-1.25) mg/cat (or 0.1-0.5 mg/
adjunct in CHF, initial dose 0.05 mg/kg kg) PO q(12)-24h
Nitroprusside Nitropress 1-2.5 µg/kg/min CRI (initial), uptitrate as 0.5-1 µg/kg/min CRI (initial), uptitrate
needed to 5-15 µg/kg/min CRI as needed to 5 µg/kg/min CRI
Nitroglycerin Nitrobid 1 1 inch q4-6h cutaneously for 24-48 1 - 1 inch q4-6h cutaneously for 24-48
2
ointment 2% Nitrol 4 -1 2 4 hours
hours
Sildenafil citrate Viagra 1-3 (-4) mg/kg PO q8-12h 1-2 mg/kg PO q8-12h
Revatio
Prazosin Minipress 0.05-0.2 mg/kg PO q8-12h 0.25-0.5 mg/cat PO q12-24h
Phenoxybenzamine Dibenzyline 0.25 mg/kg PO q8-12h or 0.5 mg/kg 2.5 mg/cat PO q8-12h or 0.5 mg/kg
q24h q(12-)24h
Acepromazine 0.01-0.05 (-0.1) mg/kg (up to 3 mg total) 0.01-0.05 mg/kg IV (IM, SC)
IV (IM, SC)
Positive Inotropic Drugs
Pimobendan Vetmedin 0.2-0.3 mg/kg PO q12h; can increase up Same, or 1.25 mg/cat PO q12h; can
to 0.5 mg/kg q8h increase up to 0.5 mg/kg q8h
Digoxin Cardoxin Oral: 0.003-0.005 mg/kg q12h; Oral: 0.007 mg/kg (or 1 of 0.125 mg
Digitek maximum 0.5 mg/day (less in some tab/cat) q48h 4
Lanoxin dogs; monitor serum concentration);
decrease by 10% for elixir
PO loading: give first 1-2 doses at twice
calculated maintenance dose
IV loading (note: not advised unless other
therapy not effective or available):
0.0025 mg/kg slow IV bolus, repeat
hourly over 4-hour period to effect (or
total of 0.01 mg/kg)
Dobutamine Dobutrex 1 µg/kg/min initial CRI; titrate upward to 1 µg/kg/min initial CRI; titrate upward
effect q15-30 min, as needed, up to to effect q15-30 min, as needed, up
20 µg/kg/min CRI to 10 µg/kg/min CRI
Dopamine Intropin 1-10 µg/kg/min CRI (start low, titrate 1-5 µg/kg/min CRI (start low, titrate
upward to effect q15-30 min, as upward to effect q15-30 min, as
needed) needed)
Amrinone Inocor 1-3 mg/kg initial bolus, IV; 10-100 µg/ Same?
kg/min CRI
Milrinone Primacor 50 µg/kg IV over 10 min initially; Same?
0.375-0.75 µg/kg/min CRI (humans)