Page 444 - The Veterinary Laboratory and Field Manual 3rd Edition

Plate 48 See also Figure A2.8 Liver, sheep. Necrosis: there are multifocal, slightly sunken areas of tan
discolouration throughout the liver, visible from the capsular surface. This is a characteristic appearance
of hepatocellular necrosis in this case as the result of Fusobacterium necrophorum infection. F. necropho-
rum usually reaches the liver via the portal circulation from the rumen and is a common sequelae to acute
rumenitis. Necrosis can be differentiated from degenerative (glycogenosis or lipidosis) changes which can
have a similar homogenous tan appearance by the fact lesions in this case are sunken consistent with
tissue loss.

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