Page 19 - การนำเสนอผลงานวิจัย

13

Memory Function Analysis in Pediatric Supratentorial Brain Tumor

Survivors at Prasat Neurological Institute

Pinnakarn Srisarakorn M.Sc. Apasri Lusawat MD.

Prasat Neurological Institute, Department of Medical Services,

Ministry of Public Health, Bangkok, Thailand

Background and Objective: In our recent research about neuro-cognitive

outcome in Thai pediatric brain tumor survivors of Prasat Neurological Institute,

we found distinct memory dysfunction in pediatric supratentorial brain tumor

focused on radiation group. In present study, we tried to identify specific

abnormalities in memory function of these patients

Methods and Results: Neuropsychological test data of 47 pediatric

supratentorial brain tumor survivors collected between 2010 and 2014 were

analyzed in memory function. Age-specific standard memory test and

intellectual subtests associated with memory function i.e. digit span,

arithmetic, information, and similarities were included. Comparing Intelligence

Quotient (IQ) and memory function in 24 patients with radiation therapy (RT) to

23 patients without RT, impaired cases were found more in those with RT than

without RT (Full IQ (FIQ): 71.4% vs 38.9% and general memory : 76.2% vs

27.8% respectively). RT group had more severe memory impairment cases

(index score < 69) than no-RT group (65%vs 21%, mean index score 53.1 vs

56.7 respectively.) The 5 of 20 memory subtests of RT group i.e. similarities,

information, arithmetic, word paired association and story memory had

significantly lower scale score than no-RT group (2.7vs 7.3, 3.7vs 6.7, 4.4 vs7.8,

4.6 vs 10.4 and 5.3 vs 6.8, respectively). Analyzing follow-up (FU) time interval

th
19 Annual Academic Meeting of Prasat Neurological Institute, 2015