Page 127 - Essential Haematology

Chapter 8 White cells: Granulocytes and monocytes / 113

Antigen
IL-3, IL-5

T lymphocyte

IL-6

TNF
IL-1 GM-CSF
Stromal
cells
G-CSF
TNF
IL-1 M-CSF

Monocyte

Endotoxin

Figure 8.4 Regulation of haemopoiesis; pathways of stimulation of leucopoiesis by endotoxin, for example from

infection. It is likely that endothelial and fi broblast cells release basal quantities of granulocyte – macrophage
colony - stimulating factor (GM - CSF) and granulocyte colony - stimulating factor (G - CSF) in the normal resting state
and that this is enhanced substantially by tumour necrosis factor (TNF) and interleukin - 1 (IL - 1) from monocytes.

8

6
Neutrophils (x 10 9 /L) 4 G-CSF

2
Controls

0
0 5 10 15 20 25 30
Days after marrow infusion

Figure 8.5 Typical effect of granulocyte colony - stimulating factor (G - CSF) on recovery of neutrophils following

autologous bone marrow transplantation.