Page 28 - Essential Haematology

14 / Chapter 1 Haemopoiesis

differentiation, functional activity or proteins (e.g. BAX) to anti - apoptotic
suppress apoptosis. proteins (e.g. BCL - 2) determines the cell

■ Transcription factors are molecules that susceptibility to apoptosis.

bind to DNA and control the transcription ■ Adhesion molecules are a large family of
of specifi c genes or gene families. glycoproteins that mediate attachment of
■ Apoptosis is a physiological process of cell marrow precursors and mature leucocytes

death resulting from activation of caspases. and platelets to extracellular matrix,
The intracellular ratio of pro - apoptotic endothelium and to each other.

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