Page 394 - Essential Haematology

380 / Chapter 27 Thrombosis and antithrombotic therapy

■ Warfarin is the most frequently used oral ■ Thrombi, if fresh, may be dissolved by

anticoagulant, the dose usually aimed to fi brinolytic agents (e.g. streptokinase) or
raise the international normalized ratio recombinant tissue plasminogen activator.
(INR) between 2.0 and 3.0. There are Antiplatelet drugs – aspirin, clopidogrel
frequent drug interactions that affect the and dipyrimadole – are used to treat
dose. arterial disorders.

■ New anticoagulants include the factor X a

inhibitor, rivaroxaban and factor II
(prothrombin) inhibitor, dabigatran.

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