Page 464 - Essential Haematology

450 / Index

Salmonella osteomyelitis, sickle cell sinus histiocytosis with massive hereditary spherocytosis 79
anaemia 102, 103 lymphadenopathy 122 indications 147, 148
schistosomiasis 391 skeletal congenital defects, Fanconi’s malaria severity 148
Schwachman–Diamond syndrome anaemia 289, 290 platelet counts 148
292, 295 skin primary myelofi brosis 211
scurvy 332 acute pattern graft-versus-host pyruvate kinase defi ciency 82
SD gene mutations 292, 295 disease 306, 307 splenic marginal zone lymphoma
selectins 13 antiphospholipid syndrome 370 265
senile purpura 332 cutaneous Hodgkin lymphoma thrombocytosis 369
serine protease 246 warm autoimmune haemolytic
activity 320, 322 mycosis fungoides 270 anaemia 83
inactivation 325 non-Hodgkin lymphoma 257 splenic marginal zone lymphoma
serum amyloid P (SAP) scan 284, Sézary syndrome 270 265
285 vascular bleeding disorders splenic pooling, increase in
severe combined immunodefi ciency 331–2 thrombocytopenia 339,
(SCID) 139 skull, thalassaemia major 95, 96 340
Sézary syndrome 257, 270 small lymphocytic lymphoma (SLL) splenomegaly 144–6
Shigella, haemolytic uraemic 235, 261 causes 147
syndrome 338 solitary plasmacytoma 281–2 CLL 236
sickle cell anaemia 91, 99–100, South-East Asian ovalocytosis 79 Felty’s syndrome 385
101, 102–4 spectrin 22 Hodgkin lymphoma 246
aplastic crises 100 spina bifi da 66, 67 platelet content 316
clinical features 100–2, 101, 102 folic acid prophylaxis 71 polycythaemia vera 205
crisis treatment 102–3 spine, multiple myeloma 274, 275 splenic marginal zone lymphoma
haemolytic crises 101 spingomyelinase defi ciency 125 265
Hb electrophoretic pattern 97 spleen splenic pooling in
homozygous disease 100, 101, anatomy 143 thrombocytopenia 339,
102–4 circulation 143 340
laboratory fi ndings 102, 104 extramedullary haemopoiesis 144 tropical 144–6, 391
molecular pathology 100 fetal haemopoiesis 2 Staphylococcus epidermidis 169, 170
red cell aplasia 295 functions 143–4 stem cell(s) 2–3
treatment 102–4 hypersplenism 146 aplastic anaemia 289, 290
vaso-occlusive crises 100, 101 imaging 144, 145, 146 bone marrow collection 300
venous thrombosis 369 immune function 144 collection 230, 298, 299
visceral sequestration crises 100 lyphoid tissue 143, 144 conditioning 300–1
sickle cell/C disease 104 non-Hodgkin lymphoma 257 donor leucocyte infusions 301
sickle cell trait 104 periarteriolar lymphatic sheath embryonic 5
sickle haemoglobin (Hb S) 21, 104 143 homing 5
sideroblastic anaemia 47–8 platelet content 316 mesenchymal 4–5
sideroblasts, ring 47 sickle cell anaemia 101–2 mobilization 5
siderotic granules 30, 144 thalassaemia major 95 myoablative conditioning 301
signal transducer and activator of see also hypersplenism non-myoablative conditioning
transcription (STAT) splenectomy 301
family of transcription autoimmune neutropenia 120 peripheral blood 230, 298, 299
factors 8, 9, 10 autoimmune thrombocytopenic pluripotent 5–6, 8
signal transduction inhibitors, purpura 336 processing 300, 301
haematological CLL 241 self-renewal 6
malignancies 175, 176 hereditary elliptocytosis 79 capacity 3, 4