Page 82 - Essential Haematology
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(a) (b)
(c) (d)
Figure 5.12 Megaloblastic changes in the bone marrow in a patient with severe megaloblastic anaemia.
(a – c) Erythroblasts showing fi ne, open stippled (primitive) appearance of the nuclear chromatin even in late
cells (pale cytoplasm with some haemoglobin formation). (d) Abnormal giant metamyelocytes and band forms.
Table 5.7 Laboratory tests for vitamin B 12 and folate defi ciency.
Result in
Test Normal values * Vitamin B 12 defi ciency Folate defi ciency
Serum vitamin B 12 160 – 925 ng/L 120 – 680 pmol/L Low Normal or
borderline
Serum folate 3.0 – 15.0 μ g/L 4 – 30 nmol/L Normal or raised Low
Red cell folate 160 – 640 μ g/L 360 – 1460 nmol/L Normal or low Low
* Normal values differ slightly with different commercial kits.