Page 89 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)

Metabolic actions

Growth and a. Perinatal lung maturation
maturation b. Normal skeletal growth

a. Normal fetal and neonatal brain development

Neurological b. Regulation of neuronal proliferation and differentiation,
myelinogenesis, neuronal outgrowth, and synapse formation
c. Normal CNS function in adults

Sympathetic a.  number of β-adrenergic receptors
nervous system b.  heart rate
function c. Tremor

d. Sweating

Cardiovascular a.  heart rate

system b.  myocardial contractility
c.  cardiac output

a.  basal metabolic rate

b. Stimulation of all metabolic pathways, both anabolic and
Metabolism catabolic
c.  carbohydrate utilization

d.  oxygen consumption
e.  heat production

2) Calcitonin

( ca & phosphate in blood)

Mechanism of action:

Direct inhibition of osteoclast activity   bone resorption  less demineralization of the
bone   release of calcium and phosphate from the bone into the blood.

Control:

Secretion is determined mainly by the plasma calcium concentration.

Source &Uses:

Salmon, taken intranasal ➔ ttt of osteoporosis.

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