Page 163 - Pharmaceutics IV (02-06-01305)

Rabies antiserum is produced in horses .Plasma from
hyperimmune horses ..conc…used for antioxidant sera .

Hepatitis

Acute sporadically or in epidemics and is caused by a
virus spread by ingesting food or water contaminated
with feaces .Epidemics of infectious hepatitis (viral
hepatitis A) have been successfully controlled by an
injection of ϒ globulin prepared from normal adult
serum although this been relatively ineffective against
serum transfusion hepatitis ( viral hepatitis B).

Prophylactic ϒ globulin is recommended to all contacts
of infectious hepatitis ,especially pregnant and post
menoposal woman ,as early as possible after exposure

and confers protection even if given as late as 6 days

before the onset of symptoms . dose 250-750 mg for
subjects under 10 years of age and 500-1500 mg for
other subjects . Modern production methods ensure
that ϒ – globulin is virus free in absence of ϒ- globulin
plasma or serum be substituted.

Measles(Rubeola)

I is highly infectious acute disease caused caused by
measles virus . The disease can be attenuated or
completely prevented by ϒ – globulin prepared from

pooled adult serum,Killed vaccine prepared by formalin
treatment of virus grown in either monkey kidney or dog

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