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Parenterals: Containers & packaging
General requirements
• Containers and closures must not interact physically or chemically
with the preparation (drug or excipients).
• They should also be robust enough to withstand the chosen
sterilization process.
• Containers should be effectively sealed to prevent the enclosed
medicine becoming contaminated with microorganisms or other
contaminants during storage prior to use.
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Parenterals: Containers & packaging
General requirements
• Because it is impossible in practice to transfer the entire volume of a
single-dose container or the last dose in a multiple-dose container into
a syringe, a slight excess in volume of the contents of ampuls and
vials over the labeled size or volume of the package is permitted.
• Dry powders are packaged in containers large enough to permit
proper shaking with the liquid component during reconstitution.
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Salma E. EL-Habashy
