Page 1262 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Index 1193

VetBooks.ir Pharmacokinetics, 696, 759 760, 943, 948, Phosphonofluoridates, 496, 497t Phytonadione. See Vitamin K 1
956, 959 962
Phosphonomethyl amino acids, 560
Phytotoxic chemicals, 553
N-(Phosphonomethyl) glycine. See Glyphosate
Phytotoxin, 903
anatoxins, 770
cadmium, 418
microcystins, 768 N-(Phosphonomethyl)homoalanine. Phytotoxin robinin, 903
PICs. See Products of incomplete combustion
See Glufosinate
Pharmacological antidotes, 1149 Phosphonothioates, 496, 497t (PICs)
Pharmacological effects, 107 108 Phosphoramidates, 496, 497t PIF. See Prolactin inhibitory factor (PIF)
Pharmacovigilance, 96 97 Phosphoramidothioates, 496, 497t Piglets, 937 938
Pharmcokinetics, fumonisin, 1004 1005 Phosphorodiamidic fluoride, 505 506 Pigment accumulation, 248, 932
Phase I hydrolysis, 244, 1044 Phosphorodithioates, 496, 497t Pigs
Phase I metabolism, 245, 250 Phosphorofluoridates, 496, 497t anticoagulant rodenticide toxicosis, 594
Phase I reactions, 134, 244 Phosphorothioates, 496, 497t fumonisin effect in, 1008t
Phase II enzymes, 134, 244 Phosphorotrithioates, 496, 497t iron toxicity in, 435
Phase III transporter systems, 245 246 Phosphorus, 201, 424 Pimephales promelas. See Flathead minnows
Phencyclidine, 396, 401 405 Photodynamic pigment, 872, 900 (Pimephales promelas)
clinical symptoms, 404 405 Photosensitization, 872 Pindone, 584
mechanism of action, 404 Photosensitizing plants, 872 874. See also PA- Pine caterpillar (Thaumetopoea pityocampa),
toxicity, 403 404 containing plants 54
toxicokinetics, 404 description and distribution, 872 Pine needles (Pinus ponderosa), 312, 860, 864
treatment, 405 prevention and treatment, 873 874 abortion, 312
Pheniramine, 376, 376t toxicology needles, 860 864
Phenobarbital, 245, 363, 364t, 390 391, 771 primary, 872, 873t distribution, 860 863
Phenolic hydroxyl groups, 110 111 secondary, 872 873, 873t prevention and treatment, 864
Phenothiazine, 203, 376, 376t Phthalates, 303 toxicology, 863 864
tranquilizers, 518 Phthalimides. pine needle-induced abortion, 864
Phenotypic sexual differentiation, 293 294 See Chloroalkylthiodicarboximides Pinus ponderosa. See Pine needles (Pinus
Phenoxy acid derivatives, 557 559 Physiologic dead space, 216 217 ponderosa)
Phenoxy compounds, 556 Physiologic differences of birds relevant to Pinus ponderosa var. ponderosa, 863
Phenoxy herbicides, 553 toxicology, 711 712 Piper betle (P. betle), 401
Phenprocoumaron, 583 584 Physiologically based toxicokinetic models Piperadines, 376, 376t
Phenyl rings, 693 (PBTK models), 133, 137 142 Piperidine alkaloids, 854 855
Phenylarsonics, 413 applications, 141 142 Piperonyl butoxide, 723 724
Phenylbutazone, 363, 364t generic tissue block, 138f Pirimicarb, 496, 502t
1-(1-Phenylcyclohexyl) piperidine. generic whole body, 138f Pit cells, 243
See Phencyclidine model construction, 137 139 Pit viper venom (Bothrops atrox), 168 169
Phenylephrine, 373 model validation, 141 Pit vipers. See Crotalids
Phenylmercury, 455 parameter estimation and identifiability, 140 Pittosporo (Pittosporum tobira), 54, 63 64
Phenylpropanolamine (PPA), 203, 373 SMZ, 138f Pivotal margin of safety study, 93
Phenylpyrazoles, 533 Physiology/mechanism of action, 949 950 PKC. See Protein kinase C (PKC)
Phenyltoloxamine, 376, 376t Physostigma venenosum (P. venenosum), 495 PKR. See RNA-activated protein kinase (PKR)
Phenytoin, 363, 364t Physostigmine, 495 “Placental Barrier”, 292
Philadelphia chromosome (Ph ), 349 Phytochemicals affecting cardiac system, 228 Placentation, 292
0
Philodendron bipinnatifidum (P. Phytoestrogens, 304 305, 817, 819, 824t Plains larkspur, 846
bipinnatifidum), 232 233 adverse health effects, 826 829 Plankothrix genera, 712
Phomopsis leptostromiformis (P. categories and selected compounds, 818t Plant hydrilla (Hydrilla verticillata), 713
leptostromiformis), 854 chemical structure of estrogen found in Plant poisoning, 837, 891
Phormidium genera, 770 animals, 817f conditions conducive to, 894
Phosgene, 73 74 mechanism of action, 823 826 diagnosis, 892 894, 892t
mechanism of action, 73 additional impact on cell functions, household plants, 894t
pharmacokinetics/toxicokinetics, 73 825 826 livestock, 893 894
toxicity, 73 74 altered signal transduction and cell pets, 893
treatment, 74 proliferation, 826 systemic effects of, 905t
Phosgene oxime (CHCl 2 NO), 79 80 ERs, 823 824 Plant(s), 54, 713, 714t, 892
mechanism of action, 79 impact on steroidogenesis, 824 825 containing cardiac glycosides, 1152t
pharmacokinetics/toxicokinetics, 79 pharmacokinectics/toxicokinetics impact, 819, 820t
toxicity, 79 absorption, 820 822 lignans, 821, 822f
treatment, 80 animal biotransformation, 820 plant-associated teratogens and
Phosphate, 381, 496, 497t, 505 506 excretion, 823 abortifacients, 312
fertilizers, 417 418 plant impact, 819 plant-induced cardiotoxicity, 227 228
ions, 424 tissue distribution, 822 823 plant-induced hepatopathy, 874
Phosphinates, 496, 497t risk assessment, 829 830 selenium, 470
Phosphine (PH 3 ), 221 222 as selective ER modulators, 808 809 sterols, 817 819, 818t
Phospholipase, 782 783 as SERMs, 809 810, 810t toxicity, 892
Phosphonates, 496, 497t treatment, 830 Plantkothrix genera, 770