Page 531 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

498 SECTION | VI Insecticides

VetBooks.ir TABLE 37.1 (Continued) Chemical Structure Example

Type of OP
Phosphorofluoridates Diisopropyl phosphorofluoridate (DFP)
O
RO P F
OR
Phosphonofluoridates Cyclosarin, Sarin, Soman
O

RO P F
R
Source: Adapted from Marrs, T.C., 1993. Organophosphate poisoning. Pharmacol. Ther. 58: 51 66.

TABLE 37.2 A Brief Chemical Description of Commonly Used OP Pesticides and Their Toxicity

Chemical Chemical Name Mol. wt. Oral LD 50 in Dermal LD 50 in
Rat (mg/kg) rabbit (mg/kg)
Acephate O,S-dimethyl acetylamidothiophosphate 183.17 866 .2000
Azinphos-ethyl O,O-diethyl S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl) 345.38 13 250
methyl] dithiophosphate
Azinphos-methyl O,O-dimethyl S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl) 317.32 5 220
methyl] dithiophosphate
Bromophos O-(4-bromo-2,5-dichlorophenyl) O,O-dimethyl 366.00 1600 2188
thiophosphate
Cadusaphos S,S-di-sec-butyl O-ethyl dithiophosphate 270.40 391 143
Carbophenothion S-{[(4-chlorophenyl)thio] methyl} O,O-diethyl 342.87 6 22
dithiophosphate
Chlorethoxyphos O,O-diethyl O-(1,2,2,2-tetrachloroethyl) 336.00 1.8 12.5
thiophosphate
Chlorfenvinphos 2-chloro-1-(2,4-dichloro-phenyl)vinyl diethyl 359.57 12 3200
phosphate
Chlorpyrifos O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) 350.59 135 2000
thiophosphate
Chlorpyrifos- O,O-dimethyl O-(3,5,6-trichloropyridin-2-yl) 322.53 941 2000
methyl thiophosphate
Coumaphos O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O- 362.77 13
diethyl thiophosphate
Crotoxyphos 1-phenylethyl (2E)-3-[(dimethoxyphosphoryl)oxy]but- 314.27 125 385
2-enoate
Cyanophos O-(4-cyanophenyl) O,O-dimethyl thiophosphate 243.22 610 800
Demeton-O O,O-diethyl O-[2-(ethylthio)ethyl] thiophosphate 258.34 2.5 8
Diazinon O,O-diethyl O-(2-isopropyl-6-methylpyrimidin-4-yl) 304.35 300 379
thiophosphate
Dichlorvos 2,2-dichlorovinyl dimethyl phosphate 220.98 25 59
(Continued )