Page 192 - Traité de chimie thérapeutique 6 Médicaments antitumoraux
P. 192
148 MÉDICAMENTS INDUISANTDES MODIFICATIONS COVALENTES DE L'ADN
Son activité in vitro et in vivo est meilleure sur les tumeurs solides (surtout celles riches
en DT-diaphorase) que surles leucémies. Il ne semble pas provoquerde myélosuppression.
BIBLIOGRAPHIE
VOIES D'ACCÈS
HATAT., SANO Y., SUGAWARA R., MATSUMAE A., KANAMORI K., SHIMA T., HOSHI T.,
Mitomycin a new antibiotic from streptomyces, J. Antibiot., SerA, 1956, 9, 141-145.
GOUREVITCH A., CHERTOW B., LEIN J., Mitomycin recovery from fermentation broth,
U.S. Patent 3, 042, 582, 1962.
LEFEMINE D.V., DANN M., BARBATSCHI F., HAUSMANN W.K., ZBINOVSKI V.,
MONNIKENDAM P., ADAM J., BOHONOS N., Isolation and characterization of mito-
mycin and other antibiotics produced by Streptomyces verticil/atus, J. Am. Chem.
Soc., 1962, 84, 3184-3185.
KISHI Y., The total synthesis of mitomycins, J. Nat. Prod., 1979, 42, 549-568.
DANISHEFSKY S.J., SCHKERYANTZ J.M., Chemical explorations driven by an enchant-
ment with mitomycinoids -A twenty year account, Synlett, 1995, 475-490.
CARACTÈRES PHYSICOCHIMIQUES
WAKAKI S., MARUMO H., TOMIOKA K., SHIMIZU G., KATO E., KAMADA H., KUDO S.,
FUJIMOTO Y., Isolation of new fractions of antitumor mitomycins, Antibiot. Chemo-
ther., 1958, 8, 228-240.
VAN LEAR G.E., Mass spectrometric studies of antibiotics - I Mass spectra of mitomycin
antibiotics, Tetrahedron, 1970, 26, 2587-2597.
RAO G.M., BEGLEITER A., LOWN J.W., PLAMBECK J.A., Electrochemical studies of
antitumor antibiotics Il. Polarographic and cyclic voltammetric studies of mitomycin C,
J. E/ectrochem. Soc., 1977, 124, 199-202.
SHIRAHATA K., HIRAYAMA N., Revised absolute configuration of mitomycin C. X-ray
analysis of 1-N-p-bromobenzoyl)mitomycin C, J. Am. Chem. Soc., 1983, 105, 7199-
7200.
3
KELLER P.J., HORNEMANN U., The ' C-NMR spectrum of mitomycin C : reassignment,
J. Nat. Prod., 1983, 46, 569-571.
BEIJNEN J.H., Mitomycin C, in Analytical profiles of drug substances, Florey K., ed.,
Academic Press, New York, 1987, vol. 16, 361-401.
KOHN H., ZEIN N., LIN X.Q., DING J.Q., KADISH K.M., Mechanistic studies on the mode
of reaction of mitomycin C under catalytic and electrochemical reductive conditions,
J. Am. Chem. Soc., 1987, 109, 1833-1840.
BORUAH R.C., SKIBO E.B., Determination of the pKa values for the mitomycin C redox
couple by tritration, pH rate profiles, and Nernst-Clark fits. Studies of methanol elimi-
nation, carbocation formation, and the carbocation/quinone methide equilibrium, J.
Org. Chem., 1995, 60, 2232-2243.
MÉCANISME D'ACTION
IYER V.N., SZYBALSKI W., A molecular mechanism of mitomycin action: linking of com-
plementary DNA strands, Proc. Natl. Acad. Sci. U.S.A., 1963, 50, 355-361.