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132 MÉDICAMENTS EN RELA 77ON A VEC DES SYSTÈMES HORMONA UX
Analogues du tolrestat
TAWADA H., SUGIYAMA Y., IKEDA H., YAMAMOTO Y. et MEGUROK., Studies on
antidiabetic agents. IX A new aldose reductase inhibitor, AD-3467 and related 4-
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WROBEL J., MILLEN J., SREDY J., DIETRICH A., GORHAM B.J., MALAMAS M.,
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MALAMAS M.S. et MILLEN J„ Quinazolineacetic acids and related analogs as aldose
reductase inhibitors. J. Med. Chem., 1991,34, 1492-1503.
MYLARI B.L, LARSON E.R., BEYER T.A., ZEMBROWSKI W.J., ALDINGER C.E., DEE
M.F., SIEGEL T.W. et SINGLETON D.H., Novel potent aldose reductase inhibitor :
3,4-dihydro-4-oxo-3-5-[(trifluoromethyl)-2-benzothiazolyl] methyl-1-phtalazineace-
tic acid (zopolrestat) and congeners ; J. Med. Chem., 1991,34,108-122.
AD-5467, Drugs of the Future, 1991, 16, 13-15.
MYLARI B.M., BEYER T.A., SCOTT P.J., ALDINGER C.E., DEE M.F., SIEGEL
T.W. et ZEMBROWSI W.J., Potent orally active aldose reductase inhibitors related
to zopolrestat : surrogates for benzothiazole side Chain. J. Med. Chem., 1992, 35,
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MYLARI B.M., ZEMBROWSKI W.J., BEYER T.A., ALDINGER C.E. et SIEGEL T.A.,
Orally active aldose reductase inhibitors : indazoleacetic, oxopyridazineacetic and
oxopyridopyridazineacetic acids. J. Med. Chem., 1992, 35, 2155-2162.
ITOH Y., AO S., NOTSU Y. et HASHIMOTO M., Novel aldose reductase inhibitors :
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quinazolin-1-yl)acetic acids. Drugs ofthe Future, 1992,17, 31-37.
Zenarestat (FR-74366) Drugs of the Future, 1993, 18, 98-99.
Epalrestat
Epalrestat, Drugs ofthe Future, 1987,12, 336-340.
Produits d’origine naturelle
DECK L.M., VANDER JAGT D. L et ROYER R.E., Gossypol and dérivatives : A new
class of aldose reductase inhibitors. J. Med. Chem., 1991, 34, 3301 -3305.
KADOR P.F. et SHARPLESS, Pharmacophor requirements of the aldose reductase
inhibitor site. Mol. Pharmacol., 1983, 24, 521-531.