Page 144 - phytochemistry I - PharmD Clinical

some tissues and antagonizing (blocking) the effects of estrogen in
others.

• Isoflavones as phytoestrogens are implicated for:

1. Treatment of some cancers.
Anti-estrogenic activity of phytoestrogens is exerted by binding with
estrogen receptors, preventing the estrogen from binding and
initiating cancer cells. This is particularly useful in reducing the risk
of hormone-associated cancers (breast, uterine, and prostate).

2. Improve cognitive abilities.
In Parkinson’s disease (PD) isoflavones have been shown to
suppress dopaminergic cell death and help in amelioration of motor
deficits. A number of isoflavones or their metabolites penetrate BBB
and thus they are of clinical benefit by reducing PD risk.

3. Prevent osteoporosis
Supplementation with soy isoflavones increase calcium retention
capacity and help maintain bone mineral densityin
postmenopausal women. Isoflavones retard bone loss almost as
effectively as estrogen.

4. Hepatoprotective
The soybean-derived isoflavone genistein helps in treating fatty
liver disease through increasing hepatic antioxidant activities,
decreasing hepatic fibrosis, and reducing lipid peroxidation.
Similarly, other isoflavones have demonstrated antioxidant, and
anti-inflammatory properties in the liver.

5. Improve immune function.
6. Maintenance of menopausal health in women.
7. Suppress CVD by improving blood lipid profiles. It lowers total and

LDL cholesterol and raises HDL in the blood vessels.

Rotenone

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