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DEVELOPMENT OF CHINESE MEDICINAL
OINTMENT FOR ECZEMA
ABSTRACT Poster Video
RESEARCH BACKGROUND
Eczema is a chronic cutaneous inflammatory disease that affects more than 7.5% of
adults in China. Its symptoms are red, itchy, and skin patches. Generally, Western
medicine uses topical corticosteroids and glucocorticoids. However, these have side
effects and drug resistance. Chinese medicine, “Tripterygium wilfordii (TW)” consists
of an active compound “celastrol” that is natural and less toxic, which possesses anti-
inflammatory and antibacterial properties. Consequently, this research project aims to
develop the TW ointment sought to alleviate eczema symptoms.
WONG CHING
METHODOLOGY
BSc (Hons) in Chinese Medicinal Quantitative analysis was used to ensure the “suitability” and “stability” of Tripterygium
Pharmacy wilfordii ointment for eczema.
Department of Food and Health • Physical experiment: odor, appearance, and natural components for cream
Sciences selection;
• Chemical experiment: Ultraviolet-Visible spectroscopy (UV-Vis) and High-
Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD)
OBJECTIVES were used for the determination of an active ingredient, “celastrol” in the TW
ointments; and
• To develop and make ointments with Biological experiment: agar plate assay with Escherichia coli (E.coli) was employed to
Tripterygium wilfordii (TW); evaluate the effectiveness of antibacterial properties in TW ointment.
• To determine the active ingredient,
“celastrol” from making TW ointment; FINDINGS
and Aqueous Cream BP was chosen since it has no odor with natural compounds. UV-
• To evaluate the antibacterial properties Vis spectroscopy and HPLC-DAD results indicated the TW ointment had an active
of TW ointment. ingredient, “celastrol”; an agar plate assay demonstrated the 1%, 2%, and 5% TW
ointments had antibacterial properties.
ABOUT THE INVESTIGATOR
I’m Ching WONG, Noelle. My interest is joining voluntary work and swimming.
Hopefully, I can work as a quality assurance/quality control professional in a Chinese
pharmaceutical factory and establish a charitable foundation in the future. My FYP
supervisor is Dr. Siu Kan LAW.
36 Student Applied Research Presentations 2024 Student Applied Research Presentations 2024
