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Disinfectants, Antimicrobial Spectrum   1217


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  VetBooks.ir  Urine Color   Cause                  Differentials (Examples)       Useful Findings
            Brown, black
                                                                                   RBC absent on UA, plasma clear, history,
                             Myoglobin
                                                    Crush injury, prolonged seizure, severe
                                                    myopathy, heatstroke
                                                                                   ammonium sulfate test
                             Methemoglobin          Congenital, oxidative injury to RBC  Chocolate-colored blood, fixed SpO 2 (75%-85%)
                             Bilirubinuria          See yellow/orange              See yellow/orange
                             Hemoglobin             See pink/red                   See pink/red
                             Trauma                 See pink/red                   See pink/red
                             Drugs or dyes          Phenolic compounds, nitrites, sulfasalazine,   History
                                                    aniline dyes, others
                             Melanin                Melanoma                       Examination, imaging studies
            Other colors (blue,   Water-soluble pigments  Consumption of food dyes, water-soluble   UA otherwise unremarkable; colors may be
            green, any)                             markers, foods (e.g., beets), or drugs (e.g.,   unnatural (e.g., fluorescent); history helpful
                                                    rifampin, methylene blue, propofol)
                             Biliverdin             Severe hepatic disease         Elevated liver enzymes, imaging studies
                             Pseudomonas infections                                Bacteriuria, pyuria
                             Porphyrias             Inherited or acquired disorders within the   Various other issues, depending on specific
                                                    heme biosynthetic pathway      disorder
           BMBT, Buccal mucosal bleeding time; RBC, red blood cell; UA, urinalysis; WBC, white blood cell.
                                                                                                                      Differentials, Lists,   and Mnemonics




            Disinfectants, Antimicrobial Spectrum



                                                                       Halogens:                        Quaternary
                                                Alkalis:   Biguanides:   Hypochlorite   Oxidizing       Ammonium
            Agent*          Alcohols  Aldehydes  Ammonia  Chlorhexidine  (Bleach)   Agents    Phenolics  Compounds
            Mycoplasmas        ++        ++        ++          ++          ++          ++       ++          +
            Gram-positive bacteria  ++   ++        +           ++          ++          ++       ++         ++
            Gram-negative bacteria  ++   ++        +           +           ++          ++       ++          +
            Pseudomonads       ++        ++        +           ±           ++          ++       ++          ±
            Enveloped viruses  +         ++        +           ++          ++          ++       ++          +
            Non-enveloped viruses  –     +         ±           –           ++          +         ± †        –
            Fungal spores      ±         +         +           ±            +          ±         +          ±
            Mycobacteria       +         ++        +           –            +          ±        ++          –
            Bacterial spores   –         +         ±           –           ++          +         –          –
           *Examples of microorganisms from each category: Mycoplasmas: Mycoplasma cynos, Mycoplasma felis; gram-positive bacteria: Staphylococcus spp, Streptococcus spp; gram-negative bacteria:
           Bordetella bronchiseptica,  Salmonella spp;  pseudomonads:  Pseudomonas aeruginosa;  enveloped viruses:  influenza  virus,  herpesvirus;  non-enveloped viruses: feline panleukopenia virus, canine
           parvovirus, feline calicivirus; fungal spores: Aspergillus spp; acid-fast bacteria: Mycobacterium fortuitum; bacterial spores: Clostridium difficile, Clostridium perfringens.
           † In general, phenols are not active against non-enveloped viruses but they do have some activity against rotaviruses. Activity against parvoviruses has not been documented.
           ++, Highly effective; +, effective; ±, limited activity; –, no activity.
           Modified from the Canadian Committee on Antibiotic Resistance. Infection Prevention and Control Best Practices for Small Animal Veterinary Clinics, 2008; https://www.wormsandgermsblog.com/files/2008/12/
           CCAR-Guidelines-Final1.pdf. Last accessed April 24, 2018.


















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