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(a) (b)
(c) (d)
(e) (f)
Figure 8.14 Gaucher ’ s disease: (a) bone marrow aspirate – a Gaucher cell with ‘ fi brillar ’ cytoplasmic pattern;
(b) spleen histology – pale clusters of Gaucher cells in the reticuloendothelial cord; (c) magnetic resonance
imaging (MRI) scan of the left knee of a patient before treatment showing Erlenmeyer fl ask deformity with
expansion of the marrow and thinning of the cortical bone; (d) following a year of glucocerebrosidase therapy
with subsequent remodelling of bone; and bone marrow trephine biopsy before (e) and after (f) 2 years of
glucocerebrosidase therapy.