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128  /  Chapter 9  White cells: Lymphocytes



                          PRIMARY LYMPHOID ORGANS

                          Bone marrow

                                               B > T
                                              CD8 > CD4





                          Thymus
                                     +
                              Cortex TdT
                                      -
                              Medulla TdT





                          SECONDARY LYMPHOID ORGANS
                          Lymph node
                                                               Mantle zone
                                     Deep                       Follicle
                                     cortical area                Cortex
                                     (paracortex)
                                    Medullary
                                    cords

                          Spleen

                                                            T-cell (marginal) area
                                                            Germinal centre
                                                            Mantle zone
                                      Red pulp


                          Blood
                              T > B
                             CD4 > CD8



                                                                                           Figure 9.2   Primary and
                                       B-cell areas     T-cell areas             secondary lymphoid organs
                                                                                 and blood. TdT, terminal
                                                                                 deoxynucleotidyl.
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