Page 595 - Atlas of Histology with Functional Correlations

FIGURE 15.4 ■ Small intestine: jejunum (transverse section). Stain:
hematoxylin and eosin. Low magnification.

Figure 15.5 | Intestinal Glands with Paneth Cells

and Enteroendocrine Cells

Extending from the intervillous spaces of the intestinal lumen through the

lamina propria (6) to the smooth muscle muscularis mucosae (5) are the
intestinal glands (1, 8). This high-magnification illustration shows the bases of
the intestinal glands (1, 8) sectioned in longitudinal (1) and cross sections (8).

Located in their bases (1, 8) are different cells. The most obvious are the
pyramid-shaped cells filled with large, acidophilic granules that displace the
nucleus toward the base of the cell. These are the Paneth cells (4, 10) and are
found in the intestinal glands throughout the length of the small intestine. As in
the villi, there are also numerous goblet cells (2) in the intestinal glands (1, 8).

In addition to the goblet cells (2), there are numerous mitotic cells (7) that
serve as stem cells for regeneration of cells that are lost from the intestinal
glands (1, 8). Also present are the enteroendocrine cells (3, 9) that are

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