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Track 9: Heat Transfer and Thermal                                            Track 10: Advanced Materials: Design,
Engineering                                                                   Processing, Characterization and
                                                                              Applications
9-69-2: HEAT TRANSFER AND THERMAL
ENGINEERING                                                                   10-31-1: ADVANCED MATERIALS: DESIGN,
                                                                              PROCESSING, CHARACTERIZATION AND
             Wednesday, November 13, 9:45AM–10:30AM                           APPLICATIONS
                                                                  Room 155E,
                                                                                                 Tuesday, November 12, 9:45AM–10:30AM
      Calvin L. Rampton Salt Palace Convention Center                                                                                            Room 255F,

Nanowarming for Regenerative Medicine                                               Calvin L. Rampton Salt Palace Convention Center
(IMECE2019-14003)                                                             Advanced Materials: Design, Processing, Characterization,
                                                                              and Applications
                      John Bischof                                            (IMECE2019-14004)
                      University of Minnesota
                                                                                                    Zhigang Suo
Abstract: This talk will explore the underlying physics and                                         Harvard University
advantages of nanoparticle-based rewarming technologies for
regenerative medicine. Gold and iron oxide nanoparticles have                 Abstract: An integrated circuit achieves its function by
unique and tunable properties that allow transduction of optical              integrating dissimilar components, and so does a living organ.
or radiofrequency (RF) electromagnetic fields to affect heating                Soft materials—tissues, elastomers, hydrogels, and ionogels—
of biomaterials at multiple scales (1 µL droplets to L containers).           are under intense development for immediate and far-reaching
Indeed, both nanoparticle types have a long history of use for                applications. Examples include tissue regeneration, synthetic
controlled heating in the treatment of cancer. This talk will                 biology, drug delivery, soft robots, ionotronics, bioelectronics,
explore the use of nanoparticle heating for a new application                 skin-attached and implanted devices, active textiles, as well as
entitled “nanowarming,” which allows both rapid and uniform                   wearable and washable devices. Nearly all applications require
rewarming of vitrified (i.e., cryopreserved) biomaterials back                 the integration of dissimilar soft materials. This talk describes
from the cryogenic state, thereby avoiding crystallization and                several recent examples of integrated soft materials that
cracking failures. This warming, which can range from 100s °C/                achieve unusual functions. Also highlighted are fundamental
min with iron oxide RF heating to 10,000,000 °C/min with laser                challenges to the mechanics and chemistry of materials, such
gold warming, addresses a rewarming technology bottleneck                     as adhesion, fatigue, and seal. Integrated soft materials open
for vitrified large (i.e., tissues and organs) and small systems               opportunities to reinvent our disciplines and ourselves.
(i.e., embryos and oocytes). New capabilities in cell, tissue, and            Bio: Zhigang Suo is Allen E. and Marilyn M. Puckett Professor
rodent organ cryopreservation, including the first zebra fish                   of Mechanics and Materials at Harvard University. He earned
embryo cryopreservation yielding live and reproducing fish, will               a bachelor’s degree from Xi'an Jiaotong University in 1985
be presented. In summary, this talk demonstrates the growing                  and a Ph.D. degree from Harvard University in 1989. Dr. Suo
opportunities for nanoparticle heating in regenerative medicine.              joined the faculty of the University of California, Santa Barbara
                                                                              in 1989, Princeton University in 1997, and Harvard University
Bio: John Bischof works in the area of thermal bioengineering                 in 2003. His research centers on the mechanics of materials.
with a focus on biopreservation, thermal therapy, and nano-                   Applications include electronics, composites, and stretchable
medicine. His awards include the ASME Van Mow Medal and                       devices. He served on the executive committee of the ASME
Fellowships in societies including Cryobiology, JSPS, ASME,                   Applied Mechanics Division.
and AIMBE. He has served as the President of the Society for
Cryobiology and Chair of the Bioengineering Division of the                                                                                                                      xliii
ASME. Dr. Bischof obtained a B.S. in Bioengineering from U.C.
Berkeley (UCB) in 1987, an M.S. from UCB and U.C. San
Francisco in 1989, and a Ph.D. in Mechanical Engineering
from UCB in 1992. After a Post-doctoral Fellowship at Harvard
in the Center for Engineering in Medicine, he joined the faculty
of the University of Minnesota in 1993. Dr. Bischof is now a
Distinguished McKnight University Professor and Kuhrmeyer
Chair in the Departments of Mechanical and Biomedical
Engineering, and the Medtronic-Bakken Endowed Chair and
Director of the Institute for Engineering in Medicine at the
University of Minnesota.
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