Page 1074 - The Toxicology of Fishes
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1054                                                       The Toxicology of Fishes


                       polymorphisms, 556                       progestins, 257, 460, 461, 462, 465, 466, 470, 471
                       polymorphonuclear neutrophils (PMNs), 495  progestogen receptors, 463
                       polynuclear aromatic hydrocarbons, in Prince   progestogens, 472, 473
                           William Sound, 928–930; see also     programmed cell death, 418; see also apoptosis
                           polycyclic aromatic hydrocarbons     progression, 535, 536–537, 563, 566
                       polyphenols, 300                         prokaryotes, gene expression in, 286
                       polysaccharide mucus, 14                 prolactin, 88, 410, 474, 702
                       polyubiquitination, 289                  proliferating cell nuclear antigen, 712
                       polyunsaturated fatty acids (PUFAs), 194, 292,   proliferation, nodular, 572
                           304                                  proline, 294
                       polyurethane, 503                        proline hydroxylase, 283
                       polyvinyl chloride (PVC), 503            promotion, 535, 536, 563, 566, 568
                       ponds, artificial, 735, 736, 737, 740, 742  proopiomelanocortin, 474
                       pons, 422                                prooxidants, 286, 290, 292, 298, 300, 303, 305,
                       pore water, 13, 37, 38, 40, 41, 42, 43        307, 619
                       porphyria, 822                           propanediol, 570
                       porphyrins, 695–696, 712                 propenals, 191
                       porphyropsin, 424                        n-propyl gallate, 204
                       portal tracts, 331, 332, 333             propylene carbonate, 119
                       potassium, 440                           prosencephalon, 419, 420, 421
                       potency, 246, 249, 429, 470, 472         prostacylins, 179
                       potential exposure, 927, 928             prostaglandin-H synthase, 208
                       Potomac River, 535, 576                  prostaglandin-H synthetase, 179
                       32 P-postlabeling (PPL), 887, 888, 891, 911  prostaglandins, 155, 179, 190, 353, 424, 461
                       P-PST, 203                               protamine sulfate, 247
                       predator–prey interactions, 428, 742     proteases, 180
                       predictive performance, 859              protein, 61, 79, 80, 95, 122, 164, 182, 235, 275,
                       pregnane X receptor (PXR), 166, 173, 188, 257,   276, 285, 292, 403, 425, 435, 444, 477, 493
                           354, 356, 357, 358, 359, 363, 366        acute-phase, 490, 494
                       pregnenolone, 188, 459, 460                  AhR, 253
                       pregnenolone-16α-carbonitrile (PCN), 173, 188,   albumin-like, 80, 83
                           355                                      amino acids, 294
                       preoptic area, 421, 458, 462                 anesthesia-like compounds, and, 429
                       preoptic–anterior hypothalamic area (POAH), 462  anion transporter, 201
                       prescription drugs, 354                      binding, 79, 109, 120, 178, 463
                       pretectum, 421                               BSEP-like, 363
                       pre-urine, 95                                C219-immunoreactive, 365
                       primary biliary cirrhosis (PBC), 360, 365    calcium-binding (calmodulin), 463
                       primary contamination, mining/smelting, 782  calcium-regulated, 441
                       primary sclerosing cholangitis (PSC), 360, 365  carrier, 63, 477
                       primordial germ cells, 711, 976, 990         catfish serum, 80
                       Prince William Sound, 695, 885, 897, 925–930  cellular receptor, 239
                       principal components analysis (PCA), 746     CNC-bZIP, 288
                       Prionace glauca, 533                         co-chaperone, 160
                       probability, of HAH effect, 856              concentration, in fish, 79
                       probits, 668                                 corepressor, 353
                       problem formulation, 760–762, 766            CYP, 158
                       procarcinogens, 5, 169, 537, 538, 575, 576   CYP1A, 163; see also CYP1A
                       prochloraz, 365, 366, 470                    CYP2B-like, 166
                       procyanin, 296                               CYP2K1, 167, 168, 211, 540
                       procymidine, 470                             CYP3A, 173, 174; see also CYP3: CYP3A
                       progesterone, 462, 465, 471                  CYP3A-like, 169
                          receptors, 470, 471                       CYPB2-like, 166
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