Page 1078 - The Toxicology of Fishes

1058 The Toxicology of Fishes

rainbow trout (Oncorhynchus mykiss) (cont.) gene expression, and, 286–291
prochloraz, and, 366 in vitro generation of, 301
pyrene uptake by, 110 mRNA, and, 288
pyrethroids, and, 809 organismal effects of, 294–297
ras gene in, 557 transcription factors, and, 287
respiratory–cardiovascular responses of, receptor activation, 244
427–428, 430, 437, 445 receptor transformation, 244
retinoblastomas in, 560 receptors, 235–259
sewage treatment works effluent, and, 972, androgen, 247, 257
974 aryl hydrocarbon, see aryl hydrocarbon
skin, 76 receptor
cadmium diffusion across, 90 concentration of, 245
lead diffusion across, 90 constitutive androstane, see constitutive
strychnine, and, 445 adrostane receptor
sulfadimethoxine binding in, 79 corticosteroid, 257
taurocholate excretion in, 86 estrogen, 247, 256–257, 287
TCB uptake by, 117 estrogen receptor-related, see estrogen
TCDD, and, 508, 842, 843, 844 receptor-related receptors
temperature, and, 569 glucocorticoid, 257, 287
thymus, 490 G-protein-coupled, 245, 257
tin, and, 503, 504 membrane steroid, 257
tissue affinity, and, 80 mineralocorticoid, 257
transforming growth factor, 494 neurotransmitter, 258
tributyltin oxide, and, 442, 443 nuclear steroid, 257
tumor necrosis factor, 494 odorant, 258
vitellogenin, and, 469, 992 olfcatory, 258
WT-1 homolog in, 560 peroxisome proliferator-activated, see
zinc, and, 476 peroxisome proliferator-activated
zinc sulfate, and, 610 receptors
Raja erinacea, 86, 196, 361, 362, 363; see also pregnane X, see pregnane X receptor
skate retinoid, 247, 257
randomly amplified polymorphic DNA (RAPD), ryanodine, 258
697, 698 thyroid hormone, 257
rare hepatocytes, 607 trace amine-associated, 258
ras, 557–558, 577 vomeronasal, 258
rate constants, 61, 240, 247 recirculation toxicity test systems, 674
absorption, 102, 116 recombination activating genes (RAGs), 496, 899
association, 240, 247 red Irish lord (Hemilepidotus hemilepidotus), 75
chemical uptake, 20, 25, 27, 28, 128, 679 red mullet (Mullus barbatus), Mrps in, 363
dissociation, 240, 247 redox cycling, 163, 178, 179, 282, 296, 297, 298,
elimination, 22, 99, 128, 131 300, 301
gastric emptying, 74 redox status, 294
metabolic, 123 reductases, 179
rays, 79, 283, 445 aldo-keto, 288
REACH legislation, 6 biliverdin, 691
reactive nitrogen species (RNS), 276, 295, 544 cytochrome P450, 179, 298
reactive oxygen intermediate (ROI), 500, 507 glutathione, 281, 286, 294, 295, 305, 607,
reactive oxygen species (ROS), 256, 273–308, 693, 694
b
468. 544, 545, 546, 547, 549, 607, 617, 889 NADH—cytochrome , 158
5
cellular effects of, 291–294 NADPH—cytochrome P450, 157, 158, 277,
endogenous cellular sources of, 276–278 282
enhanced production of, 298–300 quinone, 282—283, 294, 350
fish vs. mammals, 303–304 redundancy analysis (RDA), 746