Page 549 - Traité de chimie thérapeutique 6 Médicaments antitumoraux

21. ACÉTATE D'ELLIPTINIUM
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BIBLIOGRAPHIE

GÉNÉRALITÉS
MATHÉ G. et al., Methoxy-9 ellipticine lactate. Ill - Clinical screening : its action in acute
myeloblastic leukemia, Rev. Eur. Etud. Clin. Bio/., 1970, 15, 541-45.
LE PECQ J.B. et al., Un nouveau composé antitumoral, l'hydroxy-9 ellipticine. Action sur
la leucémie L 1210, C.R. Acad. Sc., 1973, 277, série D, 2289-91.
DAT XUONG N. et al., L'hydroxy-9 ellipticine et quelques-uns de ses dérivés, C. R. Acad.
Sc., 1975, 281, série C, 623-26.
KANSAL V.K. et POTIER P., The biogenetic, synthetic and biochemical aspects of ellip-
ticine an antitumoral alkaloid, Tetrahedron, 1986, 42 (9), 2389-2408.

PRÉPARATION
SAINSBURY M., SCHINAZI R.F., A simple synthesis of ellipticlne and 11-demethylellip-
ticine, J. Chem. Soc. Chem. Comm., 1975, 540.
MILLER R.B., STOWELL J.G., Total synthesis of ellipticine and 9-methoxyellipticine via
benzotriazole intermediates, J. Org. Chem., 1983, 48, 886-92.
PHARMACOCINÉTIQUE, MÉTABOLISME
VAN BAC N. et al., Metabolism and disposition studies of 9-hydroxy-ellipticine and 2-
methyl-9-hydroxy-ellipticinium acetate in animais. Cancer Treat. Rep., 1980, 64 (8-9),
879-87.
GOUYETTE A. et al., Pharmacokinetics of 2-methyl-9-hydroxy-ellipticinium acetate
(NSC 264137) in cancer patients (phase I study), Eur. J. Cancer Clin. Oncol., 1982,
18, 1285-92.
MONTSARRAT B. et al., Oxidative biotransformation of the antitumor agent elliptinium
acetate : structural characterization of ils human and rat urinary metabolites, J. Pharm.
Biomed. Anal., 1987, 5 (4), 341-51.

PROPRIÉTÉS PHARMACOLOGIQUES
PAOLETTI C. et al., Antitumor activity, pharmacology and toxicity of ellipticines, ellipti-
cinium and 9-hydroxy- derivatives : preliminary clinical trials of 2-methyl-9-hydroxy-
ellipticinium (NSC 264 137), Recent Resu/ts Cancer Res., 1980, 74, 107-23.
THOMAS N. et al., Time course of lipid peroxidation induced by N-2-methyl-9-hydroxy-
ellipticinium acetate or celiptium in rat renal cortex, Pharrnacol. Toxicol., 1991, 69 (2),
112-16.
MÉCANISME D'ACTION
TEWEY K.M. et al., lntercalative antltumor drugs interfere with the breakage-reunion
reaction of mammalian DNA Topoisomerase II, J. Biol. Chem., 1984, 259 (14), 9182-
87.
KANSAL V.K. et al., Interaction of nucleosides with antitumoral agents : 9-hydroxy-N-2-
methylellipticinium acetate and 9-hydroxy-N-2-methylolivacinium acetate, Tetrahe-
dron, 1985, 41 (22), 5107-20.