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            Teratogenic Effect of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) in the Development of Isa
                                                  Brown Embryos
              Herlina Pratiwi , AEP Haskito , Ani Setianingrum 2, Muhammad Aviv Firdaus 3, Adelia Nur
                                           2
                             1*
                                            Arisanti 3 & Alfyanda Faerza 3
                                               1Embryology Laboratory,
                                         ,2Veterinary Public Health Laboratory,
                                                 ,3Bachelor student,
                      Faculty of Veterinary Medicine, Brawijaya University, Puncak Dieng Eksklusif,
                                                   Malang 65145

                                    *Correspondence: herlinapratiwi.drh@ub.ac.id


                                                     ABSTRACT

                 2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD is a chemical compound resulting from the burning effect that
           is  very  dangerous  for  humans,  plants,  or  animals  which  can  cause  skin  damage,  immunotoxic,  hepatotoxic,
           carcinogenic, teratogenic, diseases on reproduction, disturbing on growth processes, neurobehavioral, and specific
           endocrine effects. In addition, this compound can also disturb embryo development and increase embryo mortality.
           This study aims to determine the teratogenic of TCDD administration on eye diameters, head diameter, head circle,
           body length., body-wide, bodyweight of Isa brown embryos. In this study, there were two  treatment groups: a
           standard  group  without  the  addition  of  TCDD, and  a  treatment  group  with  the  addition  of  TCDD  of  5  ng/egg
           dissolved in 5 µL corn oil. The treatments were given for seven days. The unpaired sample T-test analyzed the
           measurement data. The analysis showed that the teratogenic effect of TCDD had  a significant impact on eye
           diameters, head diameter, head circle, body length., body-wide, bodyweight of chicken embryos.

           Keywords: 2,3,7,8-tetrachlorodibenzo-p-dioxin, chicken embryo, TCDD, Teratogenic effect














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