Page 42 - Abstract Book ICOH4

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Teratogenic Effect of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) in the Development of Isa
Brown Embryos
Herlina Pratiwi , AEP Haskito , Ani Setianingrum 2, Muhammad Aviv Firdaus 3, Adelia Nur
2
1*
Arisanti 3 & Alfyanda Faerza 3
1Embryology Laboratory,
,2Veterinary Public Health Laboratory,
,3Bachelor student,
Faculty of Veterinary Medicine, Brawijaya University, Puncak Dieng Eksklusif,
Malang 65145

*Correspondence: herlinapratiwi.drh@ub.ac.id

ABSTRACT

2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD is a chemical compound resulting from the burning effect that
is very dangerous for humans, plants, or animals which can cause skin damage, immunotoxic, hepatotoxic,
carcinogenic, teratogenic, diseases on reproduction, disturbing on growth processes, neurobehavioral, and specific
endocrine effects. In addition, this compound can also disturb embryo development and increase embryo mortality.
This study aims to determine the teratogenic of TCDD administration on eye diameters, head diameter, head circle,
body length., body-wide, bodyweight of Isa brown embryos. In this study, there were two treatment groups: a
standard group without the addition of TCDD, and a treatment group with the addition of TCDD of 5 ng/egg
dissolved in 5 µL corn oil. The treatments were given for seven days. The unpaired sample T-test analyzed the
measurement data. The analysis showed that the teratogenic effect of TCDD had a significant impact on eye
diameters, head diameter, head circle, body length., body-wide, bodyweight of chicken embryos.

Keywords: 2,3,7,8-tetrachlorodibenzo-p-dioxin, chicken embryo, TCDD, Teratogenic effect

THE 4 INTERNATIONAL CONFERENCE ON ONE HEALTH (ICOH)
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“Strengthening Collaboration in One Health Systems”