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CLL (score 5)
10 4 10 4
10 3 10 3
CD19 PE 10 2 CD2 PE 10 2
10 1 10 1
10 0 10 0
10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4
CD5 FITC Anti-Fmc7 FITC
10 4 10 4
10 3 10 3
CD79b PE 10 2 None 10 2
10 1 10 1
10 0 10 0
10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4
CD20 FITC CD23 FITC
10 4
10 3
Lambda PE 10 2
10 1
Figure 18.4 Immunophenotypic analysis of chronic lym-
10 0 phocytic leukaemia by fl ow cytometric cell (FACS) analysis. In
10 0 10 1 10 2 10 3 10 4 this case, the cells are CD5 + , CD19 + , CD20 + , CD23 + , CD79b + ,
Kappa FITC lambda light chain + .
(a) (b) (c)
Figure 18.5 Chronic lymphocytic leukaemia: trephine biopsies showing: (a) a marked diffuse increase in
marrow lymphocytes (closely packed cells with small dense nuclei); (b) a nodular pattern of lymphocyte
accumulation (in a different patient); and (c) interstitial infi ltration.
