Page 37 - Essential Haematology
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Chapter 2 Erythropoiesis and anaemia / 23
Glucose
ATP
ADP
Glucose-6-P
Hexose
monophosphate
shunt
Fructose-6-P
ATP
ADP
Fructose-1,6-DP
Glyceraldehyde-3P Dihydroxyacetone-P
Methaemoglobin Hb NAD
reductase
pathway MetHb NADH 1,3-DPG
ADP Luebering-
Rapoport
ATP shunt
3-PG
2-PG
P-enolpyruvate
ADP
ATP
Pyruvate
Lactate
(a)
Glucose
1,3-DPG
Mutase
2,3-DPG
Phosphatase
3-PG
2-PG
Lactate
(b)
Figure 2.10 (a) The Embden – Meyerhof glycolytic pathway. (b) The Luebering – Rapoport shunt which regulates
the concentration of 2,3 - diphosphoglycerate (2,3 - DPG) in the red cell. ADP, adenosine diphosphate;
ATP, adenosine triphosphate; Hb, haemoglobin; NAD, NADH, nicotinamide adenine dinucleotide;
PG, phosphoglycerate.
