Page 452 - Essential Haematology

438 / Index

fever pregnancy 414 gastrointestinal blood loss, iron
haematological malignancies prophylactic 70–1 defi ciency 44
169–70 sickle cell anaemia 102 Gaucher’s disease 53, 122–3, 124,
Hodgkin lymphoma 246 thalassaemia major 98 125
fi brin 320, 321, 323 warm autoimmune haemolytic genetic markers, haematological
disseminated intravascular anaemia 84 malignancies 163–4
coagulation 356, 357 folinic acid 63 germinal centre 135
platelet plug stabilization 325 follicle centre lymphoma 12 generation 137
fibrin degradation products 357 follicular dendritic cells (FDCs) giant cavernous haemangioma 331

fi brinogen 323, 327 135, 137 Gilbert’s disease 78
abnormalities in liver disease 355 follicular lymphoma 258, 259, glandular fever 135
defects 367 266, 267 Glanzmann’s disease 340–1
venous thrombosis association fondaparinux 375–6 globin chains 19–20
with high levels 368 free light assay 276 breakdown 74
fi brinolysis 326–7 fresh frozen plasma (FFP) 409 genes 89, 90
testing 328 disseminated intravascular glossitis, megaloblastic anaemia 65
fi brinolytic agents 377–8 coagulation 358 glucocerebrosidase defi ciency 122
fi brinopeptides 324 haematological malignancies glucose 22, 23
fi lariasis 391, 395 167, 168 glucose-6-phosphate dehydrogenase
fl ow cytometry 161, 163 preparation 398, 411 defi ciency 22, 79–81
platelet function testing 328 thrombotic thrombocytopenic clinical features 79–80
Flt ligand (Flt-L) 7 purpura 338 diagnosis 80–1
Flt-3 ligand (Flt-3L) 10 fungal infections epidemiology 79
FLT3 gene mutations 180, 187 allogeneic stem cell infections 85
fludarabine, cold autoimmune transplantation 308, 310 inheritance 79

haemolytic anaemias 84 CLL 236 treatment 81
fl uorescent in situ hybridization haematological malignancies glutathione defi ciency 81
(FISH) 160, 161 171, 172 gluten-induced enteropathy 41,
folate 61, 62–3 fusion proteins 12, 158 45
absorption 61, 62 parenteral iron 45
function 62, 63 G glycolytic pathway defects 81–2
metabolism abnormalities 71 G 1 phase of cell cycle 10, 11 glycoproteins, platelet 316, 318
normal values 425 G 2 phase of cell cycle 10, 11 glycosylphosphatidylinositol (GPI)
reduction 62–3 gallstones, pigment anchor 86, 87
transport 62 in hereditary spherocytosis 76, gout
folate defi ciency 42, 64–5 78, 79 polycythaemia vera 205, 206
diagnosis 67, 69 sickle cell anaemia 102 primary myelofi brosis 210, 211
hyperhomocysteinaemia 367 gangrene, essential GPIIb/IIIA inhibitors, venous
laboratory tests 68 thrombocythaemia 206 thrombosis 379
malignancy 71 gastrectomy GPIIb/IIIA receptors 319, 324,
neural tube defects 66, 67 partial 41 325
pregnancy 414–15 total 41 graduated compression stockings
sideroblastic anaemia 47 vitamin B 12 defi ciency 63 377
systemic diseases 71 vitamin B 12 prophylaxis 70 graft-versus-host disease (GVHD)
tests for cause 69 gastrin, serum levels 45 acute pattern 306, 307
treatment 69–71 gastritis allogeneic stem cell
folic acid therapy 69–70 autoimmune 64 transplantation 300, 303,
hereditary spherocytosis 79 see also atrophic gastritis 306–7